Zhang Ximei, An Xinli, Zhu Shunqin, Liu Yan
School of Life Sciences, Southwest University, Chongqing 400716, China.
Sheng Wu Gong Cheng Xue Bao. 2020 Feb 25;36(2):226-240. doi: 10.13345/j.cjb.190115.
As a member of the histone lysine-specific demethylase family, KDM1A plays a pivotal role in biological processes including signal transduction, chromatin reprogramming, embryo development, hematopoiesis, glucose and lipid metabolism. Recently, increasing studies and clinical evidences suggest that the expression of KDM1A is related to initiation and development of tumors and plays a key role in regulating of initiation and development of tumors, such as prostate cancer, breast cancer, lung cancer and liver cancer. KDM1A binds to distinct complexes and mediates different downstream signaling pathways. However, KDM1A often plays an oncogenic role in the initiation and development of tumors. Based on the current literatures, we describe the latest research of KDM1A in the initiation and progression of various tumors, and summarize its mechanism of actions, to provide clues for cancer therapy.
作为组蛋白赖氨酸特异性去甲基化酶家族的一员，KDM1A在包括信号转导、染色质重编程、胚胎发育、造血、葡萄糖和脂质代谢等生物学过程中发挥着关键作用。最近，越来越多的研究和临床证据表明，KDM1A的表达与肿瘤的发生和发展有关，并在调节肿瘤的发生和发展中起关键作用，如前列腺癌、乳腺癌、肺癌和肝癌。KDM1A与不同的复合物结合并介导不同的下游信号通路。然而，KDM1A在肿瘤的发生和发展中通常发挥致癌作用。基于目前的文献，我们描述了KDM1A在各种肿瘤发生和进展中的最新研究，并总结了其作用机制，为癌症治疗提供线索。
