Que Renye, Chen Yirong, Tao Zhihui, Ge Bingjing, Li Miaohua, Fu Zhiquan, Li Yong
Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Department of Gastroenterology, Shanghai TCM Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Acta Radiol. 2020 Nov;61(11):1473-1483. doi: 10.1177/0284185120907246. Epub 2020 Mar 8.
Fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) and diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) are tools for the diagnosis of pancreatic cancer. However, comparison of their diagnostic performance remains unknown.
To indirectly compare the diagnostic value of DWI and FDG-PET/CT in the detection of pancreatic cancer.
A literature search of PubMed, Embase, and Cochrane Library electronic databases for articles published through May 2018 yielded 875 articles. For the meta-analysis, we included 26 studies evaluating the efficacy of DWI and FDG-PET/CT for determining pancreatic cancer with a total of 1377 patients. QUADAS (Quality Assessment of Diagnostic Accuracy Studies) was used to assess the study quality. Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the receiver operating characteristic curves (AUC) with their 95% confidence intervals were calculated for each individual study.
There were no significant differences between DWI and FDG-PET/CT for sensitivity, specificity, PLR, NLR, or DOR, while DWI AUC was higher than that of FDG-PET/CT for the detection of pancreatic cancer.
The diagnostic value of both DWI and FDG-PET/CT were comparable and, hence, both techniques seem to be equally useful tools for the diagnosis of pancreatic cancer.
氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）/计算机断层扫描（CT）和扩散加权磁共振成像（DWI或DW-MRI）是诊断胰腺癌的工具。然而，它们的诊断性能比较尚不清楚。
间接比较DWI和FDG-PET/CT在检测胰腺癌中的诊断价值。
检索PubMed、Embase和Cochrane图书馆电子数据库中截至2018年5月发表的文章，共获得875篇文章。对于荟萃分析，我们纳入了26项评估DWI和FDG-PET/CT诊断胰腺癌疗效的研究，共计1377例患者。采用QUADAS（诊断准确性研究质量评估）评估研究质量。计算每项研究的敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）以及受试者工作特征曲线下面积（AUC）及其95%置信区间。
DWI和FDG-PET/CT在敏感性、特异性、PLR、NLR或DOR方面无显著差异，而在检测胰腺癌方面，DWI的AUC高于FDG-PET/CT。
DWI和FDG-PET/CT的诊断价值相当，因此，这两种技术似乎都是诊断胰腺癌同样有用的工具。
