Wang Xuedong, Li Lei, Wang Linjie, Chen Min
Department of Radiology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated Jinan University), Zhuhai, China.
Department of Nuclear Medicine, Zhuhai People's Hospital (Zhuhai Hospital Affiliated Jinan University), Zhuhai, China.
Front Oncol. 2023 Oct 18;13:1026245. doi: 10.3389/fonc.2023.1026245. eCollection 2023.
The value of DWI and F-FDG PET/CT in evaluating the expression of Ki-67 and GPC-3 in HCC was compared.
Ninety-four patients with primary HCC confirmed by pathology were retrospectively divided into high- and low-Ki-67-expression groups and positive- and negative- GPC-3 groups. The ADC and SUVmax values of the lesions in both groups were measured. ROC curves were used to evaluate the identification efficiency of parameters with significant differences for each group of lesions, and AUCwas calculated. The combined ADC and SUVmax values were analyzed by binary logistic regression. The Delong test was used to compare the AUC values of the combined and single parameters. Pearson (in line with normal distribution) or Spearman (in line with abnormal distribution) correlation analysis was used to analyze the correlation.
The ADC value of the high-Ki-67-expression group was lower than that of the low-Ki-67-expression group (<0.05), and the SUVmax value of the high-expression group was higher than that of the low-expression group (<0.05). The ADC value of the positive-GPC-3 group was lower than that of the negative group (<0.0.tive group (<0.05). The combined ADC and SUVmax values in the GPC-3 group were better than those of a single parameter (<0.05). There was a strong negative correlation between the SUVmax value and ADC value in the Ki-67 group (R=-0.578, <0.001) and a weak negative correlation between the SUVmax value and ADC value in the GPC-3 group (R=-0.279, =0.006). The SUVmax value was strongly positively correlated with the Ki-67 expression index (R=0.733, <0.001), while the ADC value was strongly negatively correlated with the Ki-67 expression index (R=-0.687, <0.001).
DWI and F-FDG PET/CT can be used to evaluate the expression of Ki-67 and GPC-3 in HCC, and there is a certain correlation between the ADC value and SUVmax. Combined DWI and F-FDG PET/CT is superior to a single technique in evaluating the expression of GPC-3 in HCC patients. However, the combined model did not benefit the Ki-67 group.
比较弥散加权成像（DWI）和氟代脱氧葡萄糖正电子发射断层显像/X线计算机体层成像（F-FDG PET/CT）在评估肝细胞癌（HCC）中Ki-67和磷脂酰肌醇蛋白聚糖-3（GPC-3）表达方面的价值。
回顾性分析94例经病理确诊的原发性HCC患者，分为Ki-67高表达组与低表达组、GPC-3阳性组与阴性组。测量两组病变的表观扩散系数（ADC）值和最大标准摄取值（SUVmax）。采用受试者工作特征（ROC）曲线评估每组病变中具有显著差异的参数的鉴别效能，并计算曲线下面积（AUC）。采用二元逻辑回归分析联合ADC值和SUVmax值。采用德龙检验比较联合参数和单一参数的AUC值。采用Pearson（符合正态分布）或Spearman（符合非正态分布）相关分析进行相关性分析。
Ki-67高表达组的ADC值低于低表达组（P<0.05），高表达组的SUVmax值高于低表达组（P<0.05）。GPC-3阳性组的ADC值低于阴性组（P<0.05）。GPC-3组联合ADC值和SUVmax值优于单一参数（P<0.05）。Ki-67组中SUVmax值与ADC值呈强负相关（R=-0.578，P<0.001），GPC-3组中SUVmax值与ADC值呈弱负相关（R=-0.279，P=0.006）。SUVmax值与Ki-67表达指数呈强正相关（R=0.733，P<0.001），而ADC值与Ki-67表达指数呈强负相关（R=-0.687，P<0.001）。
DWI和F-FDG PET/CT可用于评估HCC中Ki-67和GPC-3的表达，且ADC值与SUVmax之间存在一定相关性。在评估HCC患者GPC-3表达方面，联合DWI和F-FDG PET/CT优于单一技术。然而，联合模型对Ki-67组并无优势。
