Dania Haafizah, Barliana Melisa I, Perwitasari Dyah A, Abdulah Rizky
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Magelang, Indonesia.
Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia.
J Pharm Bioallied Sci. 2019 Dec;11(Suppl 4):S580-S586. doi: 10.4103/jpbs.JPBS_211_19. Epub 2019 Dec 30.
Schizophrenia ranks the top of all mental disorders with poor prognosis. Central Java Province is in the top five of schizophrenia incidents in Indonesia. Antipsychotic is the main therapy for schizophrenia, which is divided into 2, atypical and typical. The atypical antipsychotic is more preferable because of the minimal effect of the extrapyramidal syndrome but affects the blood pressure.
To analyze the blood pressure of schizophrenia inpatients during the pre and post-use of atypical antipsychotics in RSJ Prof. Dr. Soerojo Magelang.
This study was an observational study with cohort retrospective methods.
The research was approved and reviewed by the committee of ethics and law of Prof. Dr. Soerojo Mental Hospital. The inclusion criteria are those diagnosed with schizophrenia based on Diagnostic and Statistical Manual of Mental Disorders-IV (DSM IV), aged about 17-55 years old, receiving antipsychotic atypical therapy for at least 3 months.The exclusion criteria are inpatients who also receive antidepressants and antihypertension, have a history of cardiovascular disease and hypertension, and incomplete medical records.
Wilcoxon, Mann-Whitney, and Kruskal-Wallis test.
The result of this study most of them were treated using combination risperidone and clozapine (82.1%). In this study, 43 inpatients experienced a decrease in systolic blood pressure, 57 in systolic blood pressure, 6 with no change in systolic blood pressure, 47 a decrease in diastolic blood pressure, 50 an increase in diastolic blood pressure, and 9 with no change in diastolic blood pressure.
There was no significant difference in the blood pressure before and after the treatment.
精神分裂症在所有预后不良的精神障碍中排名第一。中爪哇省是印度尼西亚精神分裂症发病率最高的五个地区之一。抗精神病药物是治疗精神分裂症的主要疗法，分为非典型和典型两种。非典型抗精神病药物因其锥体外系综合征的影响最小而更受青睐，但会影响血压。
分析梭罗佐教授马格朗医院中使用非典型抗精神病药物前后精神分裂症住院患者的血压情况。
本研究是一项采用队列回顾性方法的观察性研究。
该研究经梭罗佐教授精神病医院伦理与法律委员会批准并审核。纳入标准为根据《精神疾病诊断与统计手册》第四版（DSM-IV）诊断为精神分裂症、年龄约17-55岁、接受非典型抗精神病药物治疗至少3个月的患者。排除标准为同时接受抗抑郁药和抗高血压药治疗的住院患者、有心血管疾病和高血压病史的患者以及病历不完整的患者。
Wilcoxon检验、Mann-Whitney检验和Kruskal-Wallis检验。
本研究结果显示，大多数患者采用利培酮和氯氮平联合治疗（82.1%）。在本研究中，43例住院患者收缩压下降，57例收缩压升高，6例收缩压无变化，47例舒张压下降，50例舒张压升高，9例舒张压无变化。
治疗前后血压无显著差异。
