Department of Pancreatic Surgery, Fudan University, Shanghai Cancer Center, Shanghai 20032, China.
World J Gastroenterol. 2020 Feb 28;26(8):828-838. doi: 10.3748/wjg.v26.i8.828.
Systemic inflammation and nutrition status play an important role in cancer metastasis. The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), consisting of haemoglobin, albumin, lymphocytes, and platelets, is considered as a novel marker to reflect both systemic inflammation and nutrition status. However, no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical resection.
To evaluate the prognostic value of preoperative HALP in pancreatic cancer patients.
The preoperative serum levels of hemoglobin, albumin, lymphocyte counts, and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical resection. The relationship between postoperative survival and the preoperative level of HALP was investigated.
Low levels of HALP were significantly associated with lymph node metastasis ( = 0.002), poor tumor differentiation ( = 0.032), high TNM stage ( = 0.008), female patients ( = 0.005) and tumor location in the head of the pancreas ( < 0.001). Low levels of HALP were associated with early recurrence [7.3 mo 16.3 mo, < 0.001 for recurrence-free survival (RFS)] and short survival [11.5 mo 23.6 mo, < 0.001 for overall survival (OS)] in patients with resected pancreatic adenocarcinoma. A low level of HALP was an independent risk factor for early recurrence and short survival irrespective of sex and tumor location.
Low levels of HALP may be a significant risk factor for RFS and OS in patients with resected pancreatic cancer.
全身性炎症和营养状态在癌症转移中起着重要作用。血红蛋白、白蛋白、淋巴细胞和血小板（HALP）联合指数由血红蛋白、白蛋白、淋巴细胞和血小板组成，被认为是一种反映全身炎症和营养状态的新型标志物。然而，尚无研究探讨 HALP 与接受根治性切除术的胰腺癌患者生存之间的关系。
评估术前 HALP 在胰腺癌患者中的预后价值。
对 582 例接受根治性切除术的胰腺腺癌患者常规检测术前血清中血红蛋白、白蛋白、淋巴细胞计数和血小板计数，并对术后生存与术前 HALP 水平之间的关系进行研究。
低水平的 HALP 与淋巴结转移显著相关（=0.002）、肿瘤分化不良（=0.032）、TNM 分期较高（=0.008）、女性患者（=0.005）和肿瘤位于胰头（<0.001）有关。低水平的 HALP 与术后早期复发相关[7.3 mo 16.3 mo，无复发生存（RFS）差异有统计学意义（<0.001）]和生存时间较短[11.5 mo 23.6 mo，总生存（OS）差异有统计学意义（<0.001）]。低水平的 HALP 是独立的早期复发和生存时间较短的危险因素，与性别和肿瘤位置无关。
低水平的 HALP 可能是接受根治性切除术的胰腺癌患者 RFS 和 OS 的重要危险因素。
