术前血小板与白蛋白比值可预测胰腺导管腺癌患者胰腺切除术后的预后。
Preoperative Platelet-to-Albumin Ratio Predicts Prognosis of Patients with Pancreatic Ductal Adenocarcinoma After Pancreatic Resection.
作者信息
Shirai Yoshihiro, Shiba Hiroaki, Haruki Koichiro, Horiuchi Takashi, Saito Nobuhiro, Fujiwara Yuki, Sakamoto Taro, Uwagawa Tadashi, Yanaga Katsuhiko
机构信息
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
Division of Gene Therapy, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
出版信息
Anticancer Res. 2017 Feb;37(2):787-793. doi: 10.21873/anticanres.11378.
BACKGROUND
The aim of this study was to evaluate a novel prognostic value of preoperative platelet-to-albumin ratio (PAR) in patients resected for pancreatic cancer.
PATIENTS AND METHODS
A total of 107 patients who underwent pancreatic resection for pancreatic cancer were studied. The patients were divided into two groups as PAR ≥46.4×10 or <46.4×10 Survival data were analyzed using the log-rank test for univariate analysis and Cox proportional hazards for multivariate analysis.
RESULTS
The PAR was a significant prognostic index on univariate analysis for disease-free survival (DFS) and overall survival (OS). The PAR retained its significance on multivariate analysis for OS (hazard ratio(HR)=2.344, 95% confidence interval(CI)=1.188-4.624, p=0.014) along with tumor differentiation and nodal involvement. PAR was a significant independent prognostic index for poor DFS on multivariate analysis (HR=1.971, 95% CI=1.128-3.444, p=0.017).
CONCLUSION
The preoperative PAR is a novel significant independent prognostic index for DFS and OS in patients after pancreatic resection with curative intent.
背景
本研究旨在评估术前血小板与白蛋白比值（PAR）对接受胰腺癌切除术患者的新预后价值。
患者与方法
共研究了107例行胰腺癌胰腺切除术的患者。患者按PAR≥46.4×10或<46.4×10分为两组。生存数据采用对数秩检验进行单因素分析，采用Cox比例风险模型进行多因素分析。
结果
PAR在无病生存期（DFS）和总生存期（OS）的单因素分析中是一个显著的预后指标。在多因素分析中，PAR对OS仍具有显著性（风险比（HR）=2.344，95%置信区间（CI）=1.188 - 4.624，p = 0.014），与肿瘤分化和淋巴结受累情况相关。在多因素分析中，PAR是DFS较差的显著独立预后指标（HR = 1.971，95% CI = 1.128 - 3.444，p = 0.017）。
结论
术前PAR是行根治性切除术后胰腺癌患者DFS和OS的一个新的显著独立预后指标。
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