Cannarella Rossella, Condorelli Rosita A, Dall'Oglio Federica, La Vignera Sandro, Mongioì Laura M, Micali Giuseppe, Calogero Aldo E
Department of Clinical and Experimental Medicine, 95123 Catania, Italy.
Dermatology Clinic, University of Catania, 95123 Catania, Italy.
Int J Endocrinol. 2020 Feb 12;2020:1942126. doi: 10.1155/2020/1942126. eCollection 2020.
Increased dehydroepiandrosterone sulfate (DHEAS) levels have been reported in men with early-onset (<35 years) androgenetic alopecia (AGA). It has been suggested that a male polycystic ovarian syndrome- (PCOS-) equivalent, defined as an endocrine syndrome with a metabolic background and a PCOS-like hormonal pattern, predisposing to type II diabetes mellitus (DM II), cardiovascular and prostate diseases later in life, may occur in at least a part of these men. The gonadal function, including sperm parameters and total testosterone (TT) levels, has been investigated in a low number of these men.
The aim of the study was to assess gonadal and adrenal function in a subset of men with early-onset AGA and controls.
43 men with early-onset AGA and 36 controls were screened for DHEAS, TT, glycaemia, insulin, gonadotropins, 17-hydroxyprogesterone (17-hydroxyprogesterone (17 = 21), as those with at least one of the following parameters: body mass index (BMI) >25 kg/m, insulin resistance (IR), and/or SHBG <25 nmol/l.
Patients with early-onset AGA had higher mean (±SD) BMI (25.5 ± 3.8 vs. 23.7 ± 3.0 kg/m; < 0.05) and 17-hydroxyprogesterone (17 < 0.05) and 17 < 0.05) and 17 < 0.05) and 17 < 0.05) and 17g/dl; < 0.05) and 17 < 0.05) and 17 < 0.05) and 17 < 0.05) and 17.
Men with early-onset AGA and at least one among BMI >25 kg/m, IR, and SHBG <25 nmol/l have increased DHEAS levels and a worse gonadal steroidogenesis. They might have a greater risk to develop gonadal dysfunction later in life. These criteria may be used to define male PCOS-equivalent.
据报道，早发性（<35岁）雄激素性脱发（AGA）男性的硫酸脱氢表雄酮（DHEAS）水平升高。有人提出，一种男性多囊卵巢综合征（PCOS）等效症，定义为一种具有代谢背景和PCOS样激素模式的内分泌综合征，易导致II型糖尿病（DM II）、心血管疾病和前列腺疾病，可能至少在部分这类男性中出现。对这些男性中的少数人进行了性腺功能研究，包括精子参数和总睾酮（TT）水平。
本研究的目的是评估一部分早发性AGA男性和对照组的性腺及肾上腺功能。
对43名早发性AGA男性和36名对照组进行DHEAS、TT、血糖、胰岛素、促性腺激素、17-羟孕酮（17-羟孕酮（17 = 21）筛查，将那些具有以下至少一项参数的人纳入研究：体重指数（BMI）>25 kg/m²、胰岛素抵抗（IR）和/或性激素结合球蛋白（SHBG）<25 nmol/l。
早发性AGA患者的平均（±标准差）BMI更高（25.5±3.8 vs. 23.7±3.0 kg/m²；P<0.05），17-羟孕酮（17<0.05）以及17<0.05）以及17<0.05）以及17<0.05）以及[此处原文似乎不完整，无法准确翻译]；P<0.05）以及17<0.05）以及17<0.05）以及17<0.05）以及17。
早发性AGA且BMI>25 kg/m²、IR和SHBG<25 nmol/l中至少有一项的男性，其DHEAS水平升高，性腺类固醇生成更差。他们在晚年发生性腺功能障碍的风险可能更大。这些标准可用于定义男性PCOS等效症。
