The potency of luliconazole against clinical and environmental complex.

BACKGROUND AND OBJECTIVES

Black strains including, and , are the most cause of otomycosis with worldwide distribution. Although, amphotericin B was a Gold standard for the treatment of invasive fungal infection for several decades, it gradually replaced by fluconazole and /or voriconazole. Moreover, luliconazole, appears to offer the best potential for activity against black strains. The aim of the present study was to compare the activity luliconazole, with commonly used antifungals against clinical and environmental strains of black .

MATERIALS AND METHODS

Sixty seven (37 clinical and 30 environmental) strains of black were identified using morphological and molecular technique (β-Tubulin gene). In addition, antifungal susceptibility test was applied according to CLSI M38 A2. The results were reported as minimum inhibitory concentration (MIC) or minimum effective concentration (MEC) range, MIC or MEC, MIC or MEC and MIC geometric (GM) or MECGM.

RESULTS

was the common isolate followed by, in both clinical and environmental strains. The lowest MIC range, MIC, MIC, and MICGM was attributed to luliconazole in clinical strains. The highest resistant rate was found in amphotericin B for both clinical (86.5%) and environmental (96.7%) strains whereas 54.1% of clinical and 30% of environmental isolates were resistant to caspofungin. Clinical strains of were more sensitive to voriconazole (86.7%) than environmental strains (70.3%). On the other hand, 83.8% of clinical and 70% of environmental isolates were resistant to posaconazole.

CONCLUSION

Luliconazole versus amphotericin B, voriconazole, posaconazole and caspofungin is a potent antifungal for Nigri complex. The extremely antifungal efficacy against black strains of luliconazole, is different from those of other used antifungals.