检查的淋巴结数量对T1-2N0M0双原发性非小细胞肺癌患者术后长期生存的影响：一项监测、流行病学和最终结果（SEER）研究
Impact of examined lymph node count on long-term survival of T1-2N0M0 double primary NSCLC patients after surgery: a SEER study.
作者信息
Jiang Kan, Zhi Xiaohui, Shen Yue, Ma Yuanyuan, Su Xinyu, Zhou Liqing
机构信息
Department of Radiation Oncology, the Affiliated Huai'an Hospital of Xuzhou Medical University, the Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.
Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
出版信息
PeerJ. 2020 Feb 26;8:e8692. doi: 10.7717/peerj.8692. eCollection 2020.
PURPOSE
The relationship between examined lymph nodes (ELN) and survival has been confirmed in several single early-stage malignancies. We studied the association between the ELN count and the long-term survival of T1-2N0M0 double primary non-small cell lung cancer (DP-NSCLC) patients after surgery, based on the Surveillance, Epidemiology and End Results (SEER) database.
METHODS
A total of 948 patients were identified and their independent prognostic factors were analyzed. These factors included the ELN count, which related to overall survival (OS) and the cancer-specific survival (CSS) of synchronous ( = 426) and metachronous ( = 522) T1-2N0M0 DP-NSCLC patients after surgery.
RESULTS
X-tile analysis indicated that the cutoff value for the sum of ELNs was 22 for both OS and CSS in the synchronous DP-NSCLC group. Patients with a sum of ELNs >22 were statistically more likely to survive than those with ≤22 ELNs. X-tile analysis revealed that the ELN count of the second lesion was related to both OS and CSS in the metachronous DP-NSCLC group. The optimal cutoff value was nine. These results were confirmed using univariate and multivariate Cox regression analyses.
CONCLUSION
Our findings indicate that ELN count was highly correlated with the long-term survival of T1-2N0M0 double primary NSCLC patients after surgery.
目的
在几种单一的早期恶性肿瘤中，已证实检查淋巴结数量（ELN）与生存率之间的关系。我们基于监测、流行病学和最终结果（SEER）数据库，研究了ELN计数与T1-2N0M0双原发性非小细胞肺癌（DP-NSCLC）患者术后长期生存之间的关联。
方法
共纳入948例患者，并分析其独立预后因素。这些因素包括ELN计数，其与同步性（n = 426）和异时性（n = 522）T1-2N0M0 DP-NSCLC患者术后的总生存（OS）和癌症特异性生存（CSS）相关。
结果
X-tile分析表明，同步性DP-NSCLC组中，ELN总数的临界值对于OS和CSS均为22。ELN总数>22的患者在统计学上比ELN总数≤22的患者更有可能生存。X-tile分析显示，异时性DP-NSCLC组中第二个病灶的ELN计数与OS和CSS均相关。最佳临界值为9。这些结果通过单因素和多因素Cox回归分析得到证实。
结论
我们的研究结果表明，ELN计数与T1-2N0M0双原发性NSCLC患者术后的长期生存高度相关。
Zotero 插件