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启动子区域内白细胞介素-12B 的功能性多态性增加结直肠癌风险。

A Functional Polymorphism in the Promoter Region of Interleukin-12B Increases the Risk of Colorectal Cancer.

机构信息

Department of General Surgery, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050011, China.

Department of General Surgery, Shijiazhuang Traditional Chinese Medical Hospital, Shijiazhuang, Hebei 050051, China.

出版信息

Biomed Res Int. 2020 Feb 21;2020:2091781. doi: 10.1155/2020/2091781. eCollection 2020.

DOI:10.1155/2020/2091781
PMID:32149085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7054766/
Abstract

OBJECTIVE

To investigate whether the polymorphisms of interleukin-12B () were associated with the risk of developing colorectal cancer (CRC). . Genotypes of rs17860508 and rs3212227 were determined by polymerase chain reaction with a direct sequencing method in 329 CRC patients and 342 matched healthy control subjects. The expression of ) were associated with the risk of developing colorectal cancer (CRC).

RESULTS

Compared with TTAGAG/TTAGAG genotype of rs17860508, the GC/GC and TTAGAG/GC genotypes may significantly increase the risk of CRC (OR = 1.81, 95% CI = 1.18-2.78; OR = 1.46, 95% CI = 1.01-2.12, respectively). Furthermore, the mRNA levels of ) were associated with the risk of developing colorectal cancer (CRC). =0.009) and TTAGAG/TTAGAG (=0.009) and TTAGAG/TTAGAG (.

CONCLUSION

These data suggested that the rs17860508 GC/GC genotype might upregulate expression at the transcriptional level and thus increase the risk of CRC.) were associated with the risk of developing colorectal cancer (CRC).

摘要

目的

探讨白细胞介素-12B()基因多态性与结直肠癌（CRC）发病风险的关系。方法：采用聚合酶链反应-直接测序法检测 329 例 CRC 患者和 342 例匹配的健康对照者 rs17860508 和 rs3212227 基因型。结果：与 rs17860508 的 TTAGAG/TTAGAG 基因型相比，GC/GC 和 TTAGAG/GC 基因型可能显著增加 CRC 的发病风险（OR=1.81，95%CI=1.18-2.78；OR=1.46，95%CI=1.01-2.12）。此外，）的表达水平与结直肠癌（CRC）的发病风险相关（=0.009）和 TTAGAG/TTAGAG（=0.009）和 TTAGAG/TTAGAG（=0.009）。结论：这些数据表明，rs17860508 的 GC/GC 基因型可能在转录水平上调的表达，从而增加 CRC 的发病风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675a/7054766/ef07c09aa04d/BMRI2020-2091781.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675a/7054766/ef07c09aa04d/BMRI2020-2091781.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675a/7054766/ef07c09aa04d/BMRI2020-2091781.001.jpg

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