Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Department of Food and Human Nutritional Sciences and the Canadian Centre for Agri-Food Research in Health and Medicine, University of Manitoba, Winnipeg, Canada.
Biomed Res Int. 2020 Feb 19;2020:6910312. doi: 10.1155/2020/6910312. eCollection 2020.
Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG pathway.
骨骼作为一个有生命的器官，由约 70%的矿物质和 30%的有机成分组成。全世界约有 2 亿人患有骨质疏松症和骨质疏松症。有多种方法可以保护骨骼免受内源性和外源性风险因素的影响。有计划的体育活动是保护骨骼健康的另一种有用方法。已经研究表明，有规律的运动可以有效地调节骨骼代谢。到目前为止，已经有许多系统发现了运动如何有助于骨骼健康。以前的研究报告了运动对骨骼健康的不同作用机制，通过调节骨重塑。然而，在以前的证据中，没有全面考虑 RANKL/RANK/OPG 通路在运动和身体表现中的调节作用。因此，本综述的目的是阐明运动对骨形成和重塑的影响，重点是其在调节 RANKL/RANK/OPG 通路中的作用。
