Torle J, Dabir P D, Korsgaard U, Christiansen J, Qvist N, El-Hussuna A
Department of Surgery, Regional Hospital Randers, Midt-Jylland region, Randers, Denmark.
Department of Pathology, Regional Hospital Randers, Midt-Jylland region, Randers, Denmark.
Surg Res Pract. 2020 Feb 21;2020:6085678. doi: 10.1155/2020/6085678. eCollection 2020.
Strictures are a common complication in Crohn's disease (CD), found in more than 50% of patients. They are characterized by the excessive deposition of extracellular proteins in the tissue as a result of the chronic inflammatory process. The effect of anti-tumor necrosis factor alpha (TNF-) therapy on the development of fibrosis is not yet fully understood.
To investigate whether the degree of intestinal inflammation and fibrosis is correlated with preoperative anti-TNF-) therapy on the development of fibrosis is not yet fully understood.
This unblinded, prospective, single tertiary center, pilot cohort study included all adult patients with CD who underwent elective, laparoscopic, or open intestinal resection. Preoperative investigations included measurement of blood TNF-) therapy on the development of fibrosis is not yet fully understood.
Histopathological specimens from 10 patients with CD who underwent ileocecal or ileocolic resections were retrieved. Four of those patients were on anti-TNF-) therapy on the development of fibrosis is not yet fully understood. ) therapy on the development of fibrosis is not yet fully understood. ) therapy on the development of fibrosis is not yet fully understood. =0.01). Anti-TNF-) therapy on the development of fibrosis is not yet fully understood. ) therapy on the development of fibrosis is not yet fully understood. ) therapy on the development of fibrosis is not yet fully understood.
Patients who underwent preoperative anti-TNF- treatment had a higher fibrosis score than controls.) therapy on the development of fibrosis is not yet fully understood.
狭窄是克罗恩病（CD）的常见并发症，超过50%的患者会出现。其特征是由于慢性炎症过程导致组织中细胞外蛋白质过度沉积。抗肿瘤坏死因子α（TNF-）治疗对纤维化发展的影响尚未完全明确。
研究肠道炎症和纤维化程度是否与术前抗TNF-治疗相关，而抗TNF-治疗对纤维化发展的影响尚未完全明确。
这项非盲、前瞻性、单中心三级队列研究纳入了所有接受择期腹腔镜或开放肠道切除术的成年CD患者。术前检查包括测量血液TNF-治疗对纤维化发展的影响尚未完全明确。
检索了10例行回盲部或回结肠切除术的CD患者的组织病理学标本。其中4例患者接受抗TNF-治疗对纤维化发展的影响尚未完全明确。）治疗对纤维化发展的影响尚未完全明确。）治疗对纤维化发展的影响尚未完全明确。=0.01）。抗TNF-治疗对纤维化发展的影响尚未完全明确。）治疗对纤维化发展的影响尚未完全明确。）治疗对纤维化发展的影响尚未完全明确。
术前接受抗TNF-治疗的患者纤维化评分高于对照组。）治疗对纤维化发展的影响尚未完全明确。
