Al-Eitan Laith N, Asa'ad Abdelqader S, Battah AbdelKader H, Aljamal Hanan A
Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.
Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan.
ACS Omega. 2020 Feb 21;5(8):4172-4180. doi: 10.1021/acsomega.9b03881. eCollection 2020 Mar 3.
Synthetic cannabinoids (SCs) were developed to mimic the effects of Δ-tetrahydrocannabinol on humans. SCs were distributed in the form of herbal blends, with smoking being the main method of consumption. These synthetic compounds have a wide range of physical, behavioral, and harmful effects on the body. However, this study aimed to identify and quantify three common SCs including AB-FUBINACA, AB-CHMINACA, and XLR-11 in the seized materials from the Jordanian market by gas chromatography coupled with mass spectrometry (GC-MS). A liquid-liquid extraction sample preparation technique was applied to 100 different seized samples obtained from the Anti-Narcotics Department of Public Security in a period between 2017 and 2018. Profiling of the seized samples revealed different distributions of the targeted SCs in the obtained samples. Upon quantitation, concentrations of these SCs varied greatly within and among the samples. The use of GC-MS analysis provided a powerful technique in the detection and identification of SCs. This study revealed the current and trends of SC use in the Jordanian illicit substance market, which was previously unclear. Future studies are required to explore new SCs and their influence in different biological samples.
合成大麻素（SCs）是为了模拟Δ-四氢大麻酚对人体的作用而开发的。SCs以草药混合物的形式分布，吸烟是主要的消费方式。这些合成化合物对身体有广泛的生理、行为和有害影响。然而，本研究旨在通过气相色谱-质谱联用（GC-MS）鉴定和定量约旦市场查获材料中的三种常见合成大麻素，包括AB-FUBINACA、AB-CHMINACA和XLR-11。采用液-液萃取样品制备技术，对2017年至2018年期间从公共安全部缉毒部门获得的100个不同查获样品进行分析。对查获样品的分析表明，目标合成大麻素在所获样品中的分布不同。经定量分析，这些合成大麻素在样品内部和样品之间的浓度差异很大。GC-MS分析的应用为合成大麻素的检测和鉴定提供了一种强大的技术。本研究揭示了约旦非法物质市场中合成大麻素使用的现状和趋势，此前这一情况尚不清楚。未来需要开展研究，探索新的合成大麻素及其在不同生物样品中的影响。
