Wibowo Fajar R, Saputra Ozi A, Lestari Witri W, Koketsu Mamoru, Mukti Rino R, Martien Ronny
Chemistry Department, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, Jl Ir. Sutami 36A, Surakarta 57126, Indonesia.
Master Program of Chemistry, Graduate School of Universitas Sebelas Maret, Jl Ir. Sutami 36A, Surakarta 57126, Indonesia.
ACS Omega. 2020 Feb 20;5(8):4261-4269. doi: 10.1021/acsomega.9b04167. eCollection 2020 Mar 3.
In the current report, hollow mesoporous silica (HMS) nanoparticles were successfully prepared by means of a hard-templating method and further modified with poly(styrene sulfonate) (PSS) via radical polymerization. Structural analysis, surface spectroscopy, and thermogravimetric characterization confirmed a successful surface modification of HMS nanoparticles. A hairy PSS was clearly visualized by high-resolution transmission electron microscopy measurement, and it is grown on the surface of HMS nanoparticles. The Brunauer-Emmett-Teller surface area and average pore size of HMS nanoparticles were reduced after surface modification because of the pore-blocking effect, which indicated that the PSS lies on the surface of nanoparticles. Nevertheless, the PSS acts as a "nano-gate" to control the release of curcumin which is triggered by pH. The drug-release profile of unmodified HMS nanoparticles showed a stormed release in both pH 7.4 and 5.0 of phosphate buffer saline buffer solution. However, a slow release (9.92% of cumulative release) of curcumin was observed at pH 7.4 when the surface of HMS nanoparticles was modified by PSS. The kinetic release study showed that the curcumin release mechanism from PSS@HMS nanoparticles followed the Ritger-Peppas kinetic model, which is the non-Fickian diffusion. Therefore, the PSS-decorated HMS nanoparticles demonstrate potential for pH-triggered drug release transport.
在本报告中，通过硬模板法成功制备了中空介孔二氧化硅（HMS）纳米颗粒，并通过自由基聚合用聚（苯乙烯磺酸盐）（PSS）对其进行了进一步修饰。结构分析、表面光谱和热重表征证实了HMS纳米颗粒的表面修饰成功。通过高分辨率透射电子显微镜测量可以清楚地看到有毛发状的PSS，它生长在HMS纳米颗粒的表面。由于孔堵塞效应，表面修饰后HMS纳米颗粒的比表面积和平均孔径减小，这表明PSS位于纳米颗粒的表面。然而，PSS充当“纳米门”来控制姜黄素由pH触发的释放。未修饰的HMS纳米颗粒的药物释放曲线在pH 7.4和5.0的磷酸盐缓冲盐缓冲溶液中均显示出爆发式释放。然而，当HMS纳米颗粒的表面用PSS修饰时，在pH 7.4下观察到姜黄素的缓慢释放（累积释放率为9.92%）。动力学释放研究表明，姜黄素从PSS@HMS纳米颗粒中的释放机制遵循Ritger-Peppas动力学模型，即非菲克扩散。因此，PSS修饰的HMS纳米颗粒显示出pH触发药物释放运输的潜力。
