l-半胱氨酸修饰的纳米级金属有机骨架递送丙戊酸/顺铂用于治疗耐药性肺癌。
l-Cysteine decorated nanoscale metal-organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy.
机构信息
Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.
出版信息
Chem Commun (Camb). 2020 Apr 7;56(27):3919-3922. doi: 10.1039/c9cc09712k. Epub 2020 Mar 9.
We design multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the drug resistance of tumor cells. In vivo experiments confirm that chemotherapy combined with microwave thermal therapy (MWTT) can significantly improve the therapeutic effect of cisplatin-resistant lung cancer.
我们设计了多功能的 CDDP-VPA@ZrMOF-Cys-PEG 纳米粒子（CVZP NPs），基于丙戊酸（VPA）的特性，它可以下调血管内皮生长因子（VEGF）的表达，从而降低肿瘤细胞的耐药性。体内实验证实，化疗联合微波热疗（MWTT）可以显著提高顺铂耐药肺癌的治疗效果。
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