Cohen Erin, Coviello Caitlin, Menaker Simon, Martinez-Duarte Ernesto, Gomez Carmen, Lo Kaming, Kerr Darcy, Franzmann Elizabeth, Leibowitz Jason, Sargi Zoukaa
Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida.
Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida.
Head Neck. 2020 Aug;42(8):2021-2029. doi: 10.1002/hed.26134. Epub 2020 Mar 9.
Human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (SCC) is a well-known cause and prognostic indicator, and the utility of p16 as a surrogate marker for HPV status has been established. P16 and its relationship with HPV have not been defined in sinonasal malignancy nor has a link with outcomes been established. Patients with sinonasal SCC from 2011 to 2017 were identified from our pathology database. P16 immunohistochemistry and HPV RNA in situ hybridization were performed on tissue specimens. Forty-seven patients were included. Disease-free survival for p16+ patients was significantly higher than p16- patients (P = .043). Fewer HPV+ patients died (P = .052) or experienced recurrence (P = .0437). Odds ratio between p16 and HPV status was 14.19 (95% CI: 1.72, 442.03). Our findings demonstrate improved survival in both the p16+ and HPV+ groups and a positive association between p16 and HPV. There may be similar potential for modifying classification for HPV+ sinonasal SCC.
人乳头瘤病毒（HPV）在口咽鳞状细胞癌（SCC）中是一个众所周知的病因及预后指标，并且p16作为HPV状态替代标志物的效用已得到确立。p16及其与HPV的关系在鼻窦恶性肿瘤中尚未明确，与预后的关联也未确立。从我们的病理数据库中识别出2011年至2017年患有鼻窦SCC的患者。对组织标本进行p16免疫组化和HPV RNA原位杂交检测。共纳入47例患者。p16阳性患者的无病生存率显著高于p16阴性患者（P = 0.043）。HPV阳性患者死亡（P = 0.052）或复发（P = 0.0437）的较少。p16与HPV状态之间的比值比为14.19（95%可信区间：1.72, 442.03）。我们的研究结果表明，p16阳性组和HPV阳性组的生存率均有所提高，且p16与HPV之间存在正相关。对于HPV阳性的鼻窦SCC，在修改分类方面可能具有类似的潜力。
