Kava Christine M, Chaturvedi Anil K, Senkomago Virginia, Mix Jacqueline M, Markowitz Lauri E, Kreimer Aimée R, Unger Elizabeth R, Saraiya Mona
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Natl Cancer Inst. 2024 Dec 9. doi: 10.1093/jnci/djae320.
In addition to oropharyngeal cancers, evidence suggests there may be an etiologic role for human papillomavirus (HPV) in some other head and neck cancers arising from the oral cavity and larynx. We estimated the burden of HPV16-attributable cancers of the oral cavity (ICD-O-3 site codes C02.0-C02.3, C02.9, C03.0, C03.1, C03.9, C04.0, C04.1, C04.8, C04.9, C05.0, C05.8, C05.9, C06.0-C06.2, C06.8, C06.9) and larynx (C32.0-C32.3, C32.8, C32.9) in the United States by pooling estimates from published case studies to calculate HPV16-attributable fractions (HPV16-AFs) and applying the HPV16-AFs to 2016-2020 US Cancer Statistics data. During 2016-2020, of an average annual number of 12,612 oral cavity cancers, 3.9% (n = 497) were estimated to be attributable to HPV16. Of an average annual number of 11,170 laryngeal cancers, 2.8% (n = 309) were estimated to be attributable to HPV16. This information can improve surveillance of HPV16-attributable cancers in the US population and inform our understanding of the potential impact of HPV vaccination on cancers at these two sites.
除口咽癌外，有证据表明人乳头瘤病毒（HPV）在一些源自口腔和喉的其他头颈癌中可能具有病因学作用。我们通过汇总已发表病例研究的估计值来计算HPV16归因分数（HPV16-AFs），并将HPV16-AFs应用于2016 - 2020年美国癌症统计数据，从而估计美国口腔（ICD-O-3部位编码C02.0 - C02.3、C02.9、C03.0、C03.1、C03.9、C04.0、C04.1、C04.8、C04.9、C05.0、C05.8、C05.9、C06.0 - C06.2、C06.8、C06.9）和喉（C32.0 - C32.3、C32.8、C32.9）的HPV16相关癌症负担。在2016 - 2020年期间，平均每年12,612例口腔癌中，估计有3.9%（n = 497）归因于HPV16。平均每年11,170例喉癌中，估计有2.8%（n = 309）归因于HPV16。这些信息可以改善对美国人群中HPV16相关癌症的监测，并有助于我们了解HPV疫苗接种对这两个部位癌症的潜在影响。
