Guan Q, Liu M, Zhuang Y J, Yuan Y, Wang S S, Li J, Chen Z, Yang X L, Tang Z R, Jia H J, Ma J Y, Wang X X, Tai P G, Li J, He Y
The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China.
Institute of Geriatrics, Second Medical Center, National Clinical Research Center for Geriatrics Diseases, Beijing Key Laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing 100083, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 May 10;41(5):629-633. doi: 10.3760/cma.j.cn112338-20200223-00152.
To investigate the epidemiological characteristics of a family clustering of COVID-19. Field epidemiological survey was conducted. Case 1 of the long-term residents from Hubei province was the source of infection of this family clustering. There were 6 cases (from case 2 to case 7) infected in the whole incubation period. The incubation period was more than 14 days for 3 of the second-generation cases. Routes of transmission included respiratory droplets (from case 1 transmitted to case 6, from case 1 to her family members) and close contact (from case 1 to other cases in her family). All the age groups were generally susceptible, while elderly were easier to progress to critically ill. Besides respiratory symptoms, there were also gastrointestinal symptoms, of which diarrhea was the most common one. Family clustering had been an important part for COVID-19 cases.
为调查新型冠状病毒肺炎（COVID-19）家庭聚集性的流行病学特征，开展了现场流行病学调查。来自湖北省的长期居民病例1是此次家庭聚集性疫情的传染源。在整个潜伏期内有6例（病例2至病例7）被感染。第二代病例中有3例潜伏期超过14天。传播途径包括呼吸道飞沫传播（病例1传染给病例6、病例1传染给其家庭成员）和密切接触传播（病例1传染给其家中其他病例）。所有年龄组普遍易感，而老年人更容易进展为危重症。除呼吸道症状外，还存在胃肠道症状，其中腹泻最为常见。家庭聚集性一直是COVID-19病例的一个重要特征。
