Garg Abhinava, Singh Charan, Pradhan Deepak, Ghosh Goutam, Rath Goutam
Department of Pharmaceutics, I.S.F.College of Pharmacy, Moga, Punjab, India.
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Pharm Dev Technol. 2020 Jul;25(6):748-756. doi: 10.1080/10837450.2020.1740932. Epub 2020 Mar 18.
The current application was aimed to evaluate the therapeutic potential of selenium and ketoconazole nanoparticles loaded hyaluronic acid gel against seborrhoeic dermatitis (SD). Amalgamation of ketoconazole (antifungal medication) and selenium (pro-oxidant) in an optimized formulation setting may help in the treatment of SD. In this study, selenium and ketoconazole nanoparticles loaded hyaluronic acid (HA) hydrogel was prepared by mechanical mixing followed by sonication. Results of the optimized batch showed a mean particle size of 121 ± 12 nm for ketoconazole and 51 ± 7 nm for selenium. SEM and TEM study revealed the prepared nanoparticles are of nanoscale dimension, with smooth spherical outline. Finally, the optimized nanoparticles were incorporated into HA hydrogel. Hydrogel exhibits desirable physical, mechanical and rheological characteristics appropriate for topical application. Optimized gel formulation exhibited an enhanced permeability with better antifungal, and anti-inflammatory activities, compared with the plain drug suspension. The optimized hydrogel with ketoconazole and selenium in nanotemplate could offer a potential strategy for the treatment of SD.
当前的应用旨在评估负载透明质酸凝胶的硒和酮康唑纳米颗粒对脂溢性皮炎（SD）的治疗潜力。在优化的配方环境中，将酮康唑（抗真菌药物）和硒（促氧化剂）合并可能有助于治疗脂溢性皮炎。在本研究中，通过机械混合然后超声处理制备了负载透明质酸（HA）水凝胶的硒和酮康唑纳米颗粒。优化批次的结果显示，酮康唑的平均粒径为121±12nm，硒的平均粒径为51±7nm。扫描电子显微镜（SEM）和透射电子显微镜（TEM）研究表明，所制备的纳米颗粒具有纳米级尺寸，轮廓呈光滑球形。最后，将优化后的纳米颗粒掺入HA水凝胶中。水凝胶具有适合局部应用的理想物理、机械和流变学特性。与普通药物悬浮液相比，优化的凝胶配方具有更高的渗透性、更好的抗真菌和抗炎活性。含有纳米模板中酮康唑和硒的优化水凝胶可为脂溢性皮炎的治疗提供一种潜在策略。
