Department of Pharmaceutics, Government College of Pharmacy, Dr. Babasaheb Ambedkar Marathwada University, (BAMU, Aurangabad), India.
Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, India.
Mol Biol Rep. 2024 May 25;51(1):688. doi: 10.1007/s11033-024-09598-z.
Selenium nanoparticles (SeNPs) are an appealing carrier for the targeted delivery. The selenium nanoparticles are gaining global attention because of the potential therapeutic applications in several diseases e.g., rheumatoid arthritis (RA), inflammatory bowel disease (IBD), asthma, liver, and various autoimmune disorders like psoriasis, cancer, diabetes, and a variety of infectious diseases. Despite the fact still there is no recent literature that summarises the therapeutic applications of SeNPs. There are some challenges that need to be addressed like finding targets for SeNPs in various diseases, and the various functionalization techniques utilized to increase SeNP's stability while facilitating wide drug-loaded SeNP distribution to tumor areas and preventing off-target impacts need to focus on understanding more about the therapeutic aspects for better understanding the science behind it. Keeping that in mind we have focused on this gap and try to summarize all recent key targeted therapies for SeNPs in cancer treatment and the numerous functionalization strategies. We have also focused on recent advancements in SeNP functionalization methodologies and mechanisms for biomedical applications, particularly in anticancer, anti-inflammatory, and anti-infection therapeutics. Based on our observation we found that SeNPs could potentially be useful in suppressing viral epidemics, like the ongoing COVID-19 pandemic, in complement to their antibacterial and antiparasitic uses. SeNPs are significant nanoplatforms with numerous desirable properties for clinical translation.
硒纳米颗粒（SeNPs）是一种有吸引力的靶向递送载体。由于在几种疾病（如类风湿性关节炎（RA）、炎症性肠病（IBD）、哮喘、肝脏和各种自身免疫性疾病如牛皮癣、癌症、糖尿病和各种传染病）中的潜在治疗应用，硒纳米颗粒受到了全球关注。尽管目前尚无文献总结 SeNPs 的治疗应用。仍然存在一些需要解决的挑战，例如在各种疾病中寻找 SeNPs 的靶点，以及利用各种功能化技术来提高 SeNP 的稳定性，同时促进广泛的载药 SeNP 分布到肿瘤区域并防止脱靶影响，需要重点关注对治疗方面的更多了解，以便更好地理解其背后的科学。考虑到这一点，我们专注于这一空白，并试图总结 SeNPs 在癌症治疗中的所有最近关键靶向治疗方法和众多功能化策略。我们还重点介绍了 SeNP 功能化方法和机制在生物医学应用中的最新进展，特别是在抗癌、抗炎和抗感染治疗方面。根据我们的观察，我们发现 SeNPs 可能在抑制病毒流行方面非常有用，例如正在进行的 COVID-19 大流行，除了它们的抗菌和抗寄生虫用途。SeNPs 是具有许多临床转化所需理想特性的重要纳米平台。
