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基于全国住院患者数据库的倾向性评分匹配分析:对比颈椎后纵韧带骨化症行前路减压融合术与后路减压融合术的围手术期并发症。

Comparison of Perioperative Complications in Anterior Decompression With Fusion and Posterior Decompression With Fusion for Cervical Ossification of the Posterior Longitudinal Ligament: Propensity Score Matching Analysis Using a Nation-Wide Inpatient Database.

机构信息

Department of Orthopedic Surgery, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

出版信息

Spine (Phila Pa 1976). 2020 Aug 15;45(16):E1006-E1012. doi: 10.1097/BRS.0000000000003469.

Abstract

STUDY DESIGN

A retrospective comparative study.

OBJECTIVE

To compare the perioperative complications and costs of anterior decompression with fusion (ADF) and posterior decompression with fusion (PDF) for patients with cervical ossification of the posterior longitudinal ligament (OPLL).

SUMMARY OF BACKGROUND DATA

Surgical treatment of cervical OPLL has a high risk of various complications. ADF and PDF are effective for the treatment of cervical OPLL; however, few studies have compared the two procedures in terms of the perioperative surgical complications.

METHODS

Patients undergoing ADF and PDF for cervical OPLL from 2010 to 2016 were identified in a nation-wide inpatient database. We investigated systemic and local complications, length of hospital stay, costs for hospitalization, reoperation, and mortality. Propensity score was calculated from patients' characteristics and preoperative comorbidities, and one to one matching was performed.

RESULTS

Propensity score-matching produced 854 pairs of patients who underwent ADF and PDF. The rate of at least one systemic complication was significantly higher in the ADF group (P = 0.004). The incidence rates of postoperative respiratory failure (P = 0.034) and dysphagia (P = 0.008) were significantly higher in the ADF group. The rates of pneumonia (P = 0.06) and hoarseness (P = 0.08) also tended to be higher in the ADF group. However, no difference was found in the mortality rate (P = 0.22). In the local complications, spinal fluid leakage was significantly higher in the ADF group (P < 0.001). However, blood transfusion rate was significantly higher in the PDF group (P = 0.001). Hospital stay was significantly longer in the PDF group (P < 0.001) and the cost for hospitalization was greater in the PDF group (P < 0.001).

CONCLUSION

The present study demonstrated that perioperative complications, such as respiratory failure, dysphagia, and spinal fluid leakage, were more common in the ADF group. However, hospital stay was longer in the PDF group, and the cost for hospitalization was greater in the PDF group.

LEVEL OF EVIDENCE

摘要

研究设计

回顾性对比研究。

目的

比较颈椎后纵韧带骨化症(OPLL)患者前路减压融合(ADF)与后路减压融合(PDF)的围手术期并发症和费用。

背景资料概要

颈椎 OPLL 的手术治疗有发生各种并发症的高风险。ADF 和 PDF 是治疗颈椎 OPLL 的有效方法;然而,很少有研究比较这两种手术方法的围手术期手术并发症。

方法

在全国住院患者数据库中,确定了 2010 年至 2016 年接受 ADF 和 PDF 治疗颈椎 OPLL 的患者。我们调查了全身和局部并发症、住院时间、住院费用、再次手术和死亡率。从患者的特征和术前合并症中计算出倾向评分,并进行一对一匹配。

结果

倾向评分匹配产生了 854 对接受 ADF 和 PDF 的患者。ADF 组至少有一种全身并发症的发生率显著更高(P=0.004)。术后呼吸衰竭(P=0.034)和吞咽困难(P=0.008)的发生率在 ADF 组显著更高。肺炎(P=0.06)和声音嘶哑(P=0.08)的发生率也倾向于在 ADF 组更高。然而,死亡率无差异(P=0.22)。在局部并发症方面,ADF 组的脑脊液漏发生率显著更高(P<0.001)。然而,PDF 组的输血率显著更高(P=0.001)。PDF 组的住院时间显著更长(P<0.001),PDF 组的住院费用更高(P<0.001)。

结论

本研究表明,ADF 组的围手术期并发症如呼吸衰竭、吞咽困难和脑脊液漏更为常见。然而,PDF 组的住院时间更长,住院费用也更高。

证据水平

3 级。

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