Bioactive Azepine-Indole Alkaloids from .

Phytochemical investigation of the alkaloid extract of the aerial parts of led to the isolation and characterization of 10 azepine-indole alkaloids, i.e., cimitrypazepine (), fargesine (), nemorosines A (), and B (), nemorosinosides A-F (-), as well as two β-carboline derivatives, 10-hydroxyisodolichantoside () and 10-hydroxydolichantoside (), an isoxazole alkaloid, nemorosinoside G (), serotonin (), bufotenine (), and ()-gentianol (). Compounds - have not yet been described. These compounds were isolated by semipreparative HPLC, and their structures were determined by means of HRMS, NMR, and ECD measurements. In addition, the monoamine oxidase-A (MAO-A), MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities were evaluated. Alkaloids - inhibited the MAO-A activity with IC values of 1.4, 1.4, and 0.9 μM, respectively.