Zhang Di, Wang Ying, Shen Sunan, Hou Yayi, Chen Yugen, Wang Tingting
The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School of Nanjing University , Nanjing, China.
Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University , Nanjing, China.
Gut Microbes. 2020 Jul 3;11(4):655-679. doi: 10.1080/19490976.2020.1731287. Epub 2020 Mar 9.
Mycobiota are inseparable from human health, shaking up the unique position held by bacteria among microorganisms. What is surprising is that this seemingly small species can trigger huge changes in the human body. Dysbiosis and invasion of mycobiota are confirmed to cause disease in different parts of the body. Meanwhile, our body also produces corresponding immune changes upon mycobiota infection. Several recent studies have made a connection between intestinal mycobiota and the human immune system. In this review, we focus on questions related to mycobiota, starting with an introduction of select species, then we summarize the typical diseases caused by mycobiota in different parts of the human body. Moreover, we constructed a framework for the human anti-fungal immune system based on genetics and immunology. Finally, the progression of fungal detection methods is also reviewed.
真菌群落与人类健康密不可分，动摇了细菌在微生物中所占据的独特地位。令人惊讶的是，这种看似微小的物种能够引发人体的巨大变化。真菌群落的失调和入侵已被证实会在身体的不同部位引发疾病。与此同时，我们的身体在受到真菌群落感染时也会产生相应的免疫变化。最近的几项研究已经建立了肠道真菌群落与人类免疫系统之间的联系。在这篇综述中，我们聚焦于与真菌群落相关的问题，首先介绍一些特定的物种，然后总结真菌群落在人体不同部位引发的典型疾病。此外，我们基于遗传学和免疫学构建了人类抗真菌免疫系统的框架。最后，还综述了真菌检测方法的进展。
