Sagini João Pedro Nunes, Ligabue-Braun Rodrigo
Graduate Program in Biological Sciences (PPGBio), Federal University of Health Sciences of Porto Alegre (UFCSPA), Sarmento Leite, 245, Porto Alegre, 90050-170, Brazil.
Department of Pharmacosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Sarmento Leite, 245, Porto Alegre, 90050-170, Brazil.
Naturwissenschaften. 2024 Mar 14;111(2):16. doi: 10.1007/s00114-024-01903-x.
Heat shock proteins are constitutively expressed chaperones induced by cellular stress, such as changes in temperature, pH, and osmolarity. These proteins, present in all organisms, are highly conserved and are recruited for the assembly of protein complexes, transport, and compartmentalization of molecules. In fungi, these proteins are related to their adaptation to the environment, their evolutionary success in acquiring new hosts, and regulation of virulence and resistance factors. These characteristics are interesting for assessment of the host adaptability and ecological transitions, given the emergence of infections by these microorganisms. Based on phylogenetic inferences, we compared the sequences of HSP9, HSP12, HSP30, HSP40, HSP70, HSP90, and HSP110 to elucidate the evolutionary relationships of different fungal organisms to suggest evolutionary patterns employing the maximum likelihood method. By the different reconstructions, our inference supports the hypothesis that these classes of proteins are associated with pathogenic gains against endothermic hosts, as well as adaptations for phytopathogenic fungi.
热休克蛋白是由细胞应激诱导的组成型表达伴侣蛋白，如温度、pH值和渗透压的变化。这些存在于所有生物体中的蛋白质高度保守，被招募用于蛋白质复合物的组装、分子运输和分隔。在真菌中，这些蛋白质与它们对环境的适应性、获取新宿主的进化成功以及毒力和抗性因子的调节有关。鉴于这些微生物感染的出现，这些特性对于评估宿主适应性和生态转变很有意义。基于系统发育推断，我们比较了HSP9、HSP12、HSP30、HSP40、HSP70、HSP90和HSP110的序列，以阐明不同真菌生物体的进化关系，采用最大似然法推断进化模式。通过不同的重建，我们的推断支持这样的假设，即这些蛋白质类别与针对恒温宿主的致病获得以及植物病原真菌的适应性有关。
