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超小顺磁氧化钆纳米粒子聚（甲基乙烯基醚-alt-马来酸）涂层的体内正磁共振成像应用。

In Vivo Positive Magnetic Resonance Imaging Applications of Poly(methyl vinyl ether-alt-maleic acid)-coated Ultra-small Paramagnetic Gadolinium Oxide Nanoparticles.

机构信息

Department of Chemistry and Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu 41566, Korea.

Division of RI-Convergence Research, Korea Institute of Radiological & Medical Science (KIRAMS), Seoul 01817, Korea.

出版信息

Molecules. 2020 Mar 5;25(5):1159. doi: 10.3390/molecules25051159.

DOI:10.3390/molecules25051159
PMID:32150823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7179159/
Abstract

The study of ultra-small paramagnetic gadolinium oxide (GdO) nanoparticles (NPs) as in vivo positive (T) magnetic resonance imaging (MRI) contrast agents is one of the most attractive fields in nanomedicine. The performance of the GdO NP imaging agents depends on the surface-coating materials. In this study, poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) was used as a surface-coating polymer. The PMVEMA-coated paramagnetic ultra-small GdO NPs with an average particle diameter of 1.9 nm were synthesized using the one-pot polyol method. They exhibited excellent colloidal stability in water and good biocompatibility. They also showed a very high longitudinal water proton spin relaxivity (r) value of 36.2 smM (r/r = 2.0; r = transverse water proton spin relaxivity) under a 3.0 tesla MR field which is approximately 10 times higher than the r values of commercial molecular contrast agents. High positive contrast enhancements were observed in in vivo T MR images after intravenous administration of the NP solution sample, demonstrating its potential as a T MRI contrast agent.

摘要

超小顺磁氧化钆（GdO）纳米粒子（NPs）作为体内正（T）磁共振成像（MRI）对比剂的研究是纳米医学中最具吸引力的领域之一。GdO NP 成像剂的性能取决于表面涂层材料。在这项研究中，聚（甲基乙烯基醚-共-马来酸）（PMVEMA）被用作表面涂层聚合物。采用一锅多醇法合成了平均粒径为 1.9nm 的 PMVEMA 包覆的超小顺磁 GdO NPs。它们在水中表现出优异的胶体稳定性和良好的生物相容性。在 3.0 特斯拉磁共振场下，它们表现出非常高的纵向水质子自旋弛豫率（r）值为 36.2 smM（r/r = 2.0；r = 横向水质子自旋弛豫率），约为商业分子对比剂的 r 值的 10 倍。静脉注射 NP 溶液样品后，在体内 T 磁共振图像中观察到高正对比增强，表明其作为 T MRI 对比剂的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/aaef6f3e7fcc/molecules-25-01159-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/e9de76370d8d/molecules-25-01159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/44a624e1cdac/molecules-25-01159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/1dd027bfd353/molecules-25-01159-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/1dd75bc70b8e/molecules-25-01159-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/cce8721f78d9/molecules-25-01159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/8c8ec1ce576a/molecules-25-01159-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/e62053015a83/molecules-25-01159-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/aaef6f3e7fcc/molecules-25-01159-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/e9de76370d8d/molecules-25-01159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/44a624e1cdac/molecules-25-01159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/1dd027bfd353/molecules-25-01159-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/1dd75bc70b8e/molecules-25-01159-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/cce8721f78d9/molecules-25-01159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/8c8ec1ce576a/molecules-25-01159-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/e62053015a83/molecules-25-01159-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/7179159/aaef6f3e7fcc/molecules-25-01159-g008.jpg

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