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稳定且无毒的超小氧化钆纳米颗粒胶体（涂层材料 = 聚丙烯酸）作为高性能磁共振成像造影剂。

Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance magnetic resonance imaging contrast agents.

作者信息

Miao Xu, Ho Son Long, Tegafaw Tirusew, Cha Hyunsil, Chang Yongmin, Oh In Taek, Yaseen Ahmad Mohammad, Marasini Shanti, Ghazanfari Adibehalsadat, Yue Huan, Chae Kwon Seok, Lee Gang Ho

机构信息

Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU) Taegu 41566 South Korea

Department of Molecular Medicine and Medical & Biological Engineering, DNN, School of Medicine, KNU and Hospital Taegu 41566 South Korea

出版信息

RSC Adv. 2018 Jan 16;8(6):3189-3197. doi: 10.1039/c7ra11830a. eCollection 2018 Jan 12.

DOI:10.1039/c7ra11830a
PMID:35541201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9077528/
Abstract

For use as positive ( ) magnetic resonance imaging contrast agents (MRI-CAs), gadolinium oxide (GdO) nanoparticle colloids ( nanoparticles coated with hydrophilic ligands) should be stable, non-toxic, and ultrasmall in particle diameter for renal excretion. In addition, they should have a high longitudinal water proton relaxivity ( ) and / ratio that is close to one ( = transverse water proton relaxivity) for high-performance. In this study, we report ultrasmall GdO nanoparticle colloids [coating material = polyacrylic acid, = ∼5100 Da] satisfying these conditions. The particle diameter was monodisperse with an average value of 2.0 ± 0.1 nm. The colloidal suspension exhibited a high value of 31.0 ± 0.1 s mM and / ratio of 1.2, where was ∼8 times higher than that of commercial Gd-chelates: the cooperative induction model was proposed to explain this. The effectiveness of the colloidal suspension as a high-performance MRI-CA was confirmed by taking MR images in a mouse after intravenous administration. Highly positive contrast enhancements were observed in various organs of the mouse such as the liver, kidneys, and bladder. The colloidal suspension was then excreted through the bladder.

摘要

作为阳性（ ）磁共振成像造影剂（MRI-CAs）使用时，氧化钆（GdO）纳米颗粒胶体（涂有亲水性配体的纳米颗粒）应具备稳定性、无毒且粒径超小以便通过肾脏排泄。此外，它们应具有高纵向水质子弛豫率（ ）以及接近1的 / 比率（ = 横向水质子弛豫率）以实现高性能。在本研究中，我们报道了满足这些条件的超小GdO纳米颗粒胶体[涂层材料 = 聚丙烯酸， = ∼5100 Da]。粒径呈单分散，平均值为2.0 ± 0.1 nm。胶体悬浮液表现出31.0 ± 0.1 s mM的高 值和1.2的 / 比率，其中 比市售钆螯合物高约8倍：为此提出了协同诱导模型。静脉注射后在小鼠体内采集 MR图像，证实了该胶体悬浮液作为高性能 MRI-CA的有效性。在小鼠的各种器官如肝脏、肾脏和膀胱中观察到高度阳性的对比增强。然后胶体悬浮液通过膀胱排出。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/6d76db461496/c7ra11830a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/31f54639bb6a/c7ra11830a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/cf80bd1a8fe5/c7ra11830a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/3ec610c8fc44/c7ra11830a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/4f11b5881383/c7ra11830a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/95f632c903ae/c7ra11830a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/342961dcf080/c7ra11830a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/02a2487ed5c7/c7ra11830a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/5b4760342604/c7ra11830a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/6d76db461496/c7ra11830a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/31f54639bb6a/c7ra11830a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/cf80bd1a8fe5/c7ra11830a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/3ec610c8fc44/c7ra11830a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/4f11b5881383/c7ra11830a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/95f632c903ae/c7ra11830a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/342961dcf080/c7ra11830a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/02a2487ed5c7/c7ra11830a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/5b4760342604/c7ra11830a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e57/9077528/6d76db461496/c7ra11830a-f9.jpg

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本文引用的文献

[1]
Surfactant-free Gd(3+)-ion-containing carbon nanotube MRI contrast agents for stem cell labeling.

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