Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, College of Human Medicine, Grand Rapids, MI 49503, USA.
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48202, USA.
Int J Mol Sci. 2020 Mar 5;21(5):1775. doi: 10.3390/ijms21051775.
The NFκB protein family regulates numerous pathways within the cell-including inflammation, hypoxia, angiogenesis and oxidative stress-all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention.
NFκB 蛋白家族在细胞内调节众多途径，包括炎症、缺氧、血管生成和氧化应激，所有这些都与胎盘发育有关。胎盘是妊娠期间发育的关键器官，主要功能是提供和转运胎儿生长和发育所需的营养物质。在妊娠期间的许多疾病中，如胎儿生长受限、流产和子痫前期 (PE)，都可以观察到异常的胎盘发育。NFκB 在患有 PE 的妇女的胎盘中高度表达，但其对该综合征的贡献尚不完全清楚。在这篇综述中，我们讨论了 NFκB 在胎盘中的分子作用和相关途径，并强调了需要关注的研究领域。
