Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Center for Biophysics and Biochemistry (CBB), Venezuelan Institute for Scientific Research (IVIC), AP 21827, Caracas 1020A, Venezuela; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic.
Biochim Biophys Acta Mol Basis Dis. 2020 Feb 1;1866(2):165354. doi: 10.1016/j.bbadis.2018.12.005. Epub 2018 Dec 24.
The role of oxidative stress in the physiopathology of human pregnancy is of particular interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a normal systemic inflammatory response, which results in high amounts of circulating reactive oxygen species (ROS) and reactive nitrogen species (RNS). Both ROS and RNS play an important role as secondary messengers in many intracellular signalling cascades. However, they can also exert critical effects on pathological processes involving the pregnant woman. ROS, RNS and antioxidants establish a balance that determines the oxidation status of animals and humans. This review focuses on the mechanism of oxidative stress in pregnancy as well as its involvement and consequences on the human pregnancy-specific clinical syndrome preeclampsia.
氧化应激在人类妊娠生理病理学中的作用尤其受到关注。众所周知，妊娠会增加氧化应激，主要由正常的全身炎症反应引起，导致大量循环活性氧（ROS）和活性氮（RNS）的产生。ROS 和 RNS 作为许多细胞内信号级联反应的第二信使，发挥着重要作用。然而，它们也可以对涉及孕妇的病理过程产生关键影响。ROS、RNS 和抗氧化剂之间建立了一种平衡，决定了动物和人类的氧化状态。这篇综述重点介绍了妊娠氧化应激的机制，以及其对人类妊娠特有的临床综合征子痫前期的作用和后果。
