Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Gifu 501-0296, Japan.
Department of Oral Health and Preventive Dentistry, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan.
Int J Environ Res Public Health. 2020 Mar 5;17(5):1694. doi: 10.3390/ijerph17051694.
Deep and subcortical white matter hyperintensity (DSWMH) lesions are a small-vessel disease of the brain. The aim of this cross-sectional study was to investigate the relationship between DSWMH lesions and periodontal status in Japanese adults who participated in a health check. We enrolled 444 consecutive participants (mean age, 54.5 years) who received both brain and oral health evaluation services at the Asahi University Hospital. Magnetic resonance imaging was used to detect DSWMH lesions. Periodontal status was assessed using the community periodontal index. Of the study participants, 215 (48.4%) had DSWMH lesions. Multivariate logistic regression showed that the presence of DSWMH lesions was significantly related to age ≥ 65 years (vs. < 65 years, odds ratio [OR] = 2.984, 95% confidence interval [CI] = 1.696-5.232), systolic blood pressure ≥ 140 mmHg (vs. < 140 mmHg, OR = 2.579, 95% CI = 1.252-5.314), the presence of ≥ 28 teeth (vs. < 28 teeth, OR = 0.635, 95% CI = 0.420-0.961), and probing pocket depth (PPD) ≥ 6 mm (vs. PPD < 6 mm, OR = 1.948, 95% CI = 1.132-3.354) after adjustment for confounding factors. Having PPD ≥ 6 mm may be a risk factor for DSWMH lesions in Japanese adults.
脑深部和皮质下脑白质高信号（DSWMH）病变是一种脑小血管疾病。本横断面研究旨在探讨日本成年人在健康检查中脑深部和皮质下脑白质高信号病变与牙周状况之间的关系。我们纳入了在旭大学医院接受脑部和口腔健康评估服务的 444 名连续参与者（平均年龄 54.5 岁）。使用磁共振成像（MRI）检测 DSWMH 病变。使用社区牙周指数（CPI）评估牙周状况。在研究参与者中，215 名（48.4%）患有 DSWMH 病变。多变量逻辑回归显示，DSWMH 病变的存在与年龄≥65 岁（与<65 岁相比，优势比[OR] = 2.984，95%置信区间[CI] = 1.696-5.232）、收缩压≥140mmHg（与<140mmHg 相比，OR = 2.579，95%CI = 1.252-5.314）、≥28 颗牙齿（与<28 颗牙齿相比，OR = 0.635，95%CI = 0.420-0.961）和探诊袋深度（PPD）≥6mm（与 PPD<6mm 相比，OR = 1.948，95%CI = 1.132-3.354）有关，校正混杂因素后。PPD≥6mm 可能是日本成年人 DSWMH 病变的一个危险因素。
