Saito T, Shimazaki Y, Kiyohara Y, Kato I, Kubo M, Iida M, Yamashita Y
Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
J Periodontal Res. 2005 Aug;40(4):346-53. doi: 10.1111/j.1600-0765.2005.00813.x.
Recent studies have reported a relationship between obesity and periodontal disease. Obesity is the strongest risk factor for type 2 diabetes, which is, in turn, a risk factor for periodontal disease. An oral glucose tolerance test is necessary to diagnose diabetes; however, no study has examined the relationship between obesity and periodontal disease by taking oral glucose tolerance test results into consideration.
In all, 584 Japanese women aged between 40 and 79 years old, with at least 10 teeth, underwent health examinations. Body mass index, waist-hip ratio, body fat, and oral glucose tolerance test results were used as independent variables with known risk factors for periodontal disease. Mean probing pocket depth and mean attachment loss were used as the dependent variables.
In all of the analyses, body mass index, body fat, and waist--hip ratio were significantly associated with the highest quintile of mean probing pocket depth, even when adjusted for oral glucose tolerance test results. In the multivariate analysis, the subjects with the highest quartile of body mass index had a significantly higher odds ratio (OR) for the highest quintile of mean probing pocket depth [OR, 4.3; 95% confidence interval (CI), 2.1--8.9; p<0.001], whereas neither impaired glucose tolerance nor diabetes were significantly associated with deep pockets. The relationships between the obesity indexes and mean attachment loss did not reach statistical significance.
Obesity was associated with deep pockets in Japanese women, even after adjusting for oral glucose tolerance test.
最近的研究报道了肥胖与牙周疾病之间的关系。肥胖是2型糖尿病的最强风险因素，而2型糖尿病又是牙周疾病的一个风险因素。诊断糖尿病需要进行口服葡萄糖耐量试验；然而，尚无研究通过考虑口服葡萄糖耐量试验结果来探讨肥胖与牙周疾病之间的关系。
共有584名年龄在40至79岁之间、至少有10颗牙齿的日本女性接受了健康检查。体重指数、腰臀比、体脂和口服葡萄糖耐量试验结果被用作牙周疾病已知风险因素的自变量。平均探诊深度和平均附着丧失被用作因变量。
在所有分析中，即使在根据口服葡萄糖耐量试验结果进行调整后，体重指数、体脂和腰臀比仍与平均探诊深度的最高五分位数显著相关。在多变量分析中，体重指数处于最高四分位数的受试者，其平均探诊深度最高五分位数的优势比（OR）显著更高[OR，4.3；95%置信区间（CI），2.1 - 8.9；p<0.001]，而糖耐量受损和糖尿病与深牙周袋均无显著关联。肥胖指数与平均附着丧失之间的关系未达到统计学显著性。
即使在根据口服葡萄糖耐量试验进行调整后，肥胖仍与日本女性的深牙周袋有关。
