Vaughan L M, Milavetz G, Weinberger M M, Smith G D, Merrick J G
Pediatric Allergy/Pulmonary Division, College of Pharmacy, University of Iowa, Iowa City 52242.
Drug Intell Clin Pharm. 1988 Sep;22(9):684-7. doi: 10.1177/106002808802200906.
Assessment in young children of the bioavailability of slow-release theophylline formulations is hampered by the requirement for frequent blood sampling. Calculations of bioavailability from serial serum and passively absorbed saliva samples were therefore compared in six 9- to 12-year-old asthmatic children receiving multiple doses of Theo-Dur Sprinkle every 12 hours, using Theo-Dur tablets, a previously characterized formulation, as a reference. Results indicated 85 +/- 5 percent and 82 +/- 8 percent (mean +/- SEM) relative bioavailability based on serum and salivary measurements, respectively. Correlation coefficient for serum and passively absorbed saliva bioavailabilities was 0.90. Passively absorbed saliva provides an acceptably accurate, noninvasive method for theophylline bioavailability assessment and may be a useful alternative for bioavailability studies in young children.
频繁采血的要求妨碍了对幼儿缓释茶碱制剂生物利用度的评估。因此，在6名9至12岁的哮喘儿童中进行了比较，这些儿童每12小时接受多剂量的Theo-Dur Sprinkle治疗，以先前已明确特性的Theo-Dur片剂作为对照，计算连续血清样本和被动吸收唾液样本的生物利用度。结果表明，基于血清测量和唾液测量的相对生物利用度分别为85±5%和82±8%（平均值±标准误）。血清生物利用度和被动吸收唾液生物利用度的相关系数为0.90。被动吸收唾液为茶碱生物利用度评估提供了一种可接受的准确、非侵入性方法，可能是幼儿生物利用度研究的一种有用替代方法。
