Richmond R G, Sawyer W T, Aiello P D, Lindley C M
Smith Kline & French Laboratories, Raleigh, NC.
Drug Intell Clin Pharm. 1988 Sep;22(9):696-9. doi: 10.1177/106002808802200910.
A young adult male patient presented with an excessively prolonged prothrombin time (greater than 90 sec) following approximately two weeks of therapy with oral warfarin sodium, in doses between 2.5 and 5 mg/d. Repeated administration of vitamin K and fresh frozen plasma was required to reverse the anticoagulation and maintain a normalized prothrombin time. Serial warfarin plasma concentration measurements were used to interpret the apparently unusual prothrombin time response profile and to detect the possibility of covert drug ingestion.
一名年轻成年男性患者在口服华法林钠治疗约两周后出现凝血酶原时间过度延长（超过90秒），剂量为每日2.5至5毫克。需要反复给予维生素K和新鲜冰冻血浆来逆转抗凝作用并维持凝血酶原时间正常化。连续测定华法林血浆浓度以解释明显异常的凝血酶原时间反应情况，并检测是否存在隐匿性药物摄入的可能性。
