Division of Endocrinology, University of Iowa Hospitals and Clinics, Room E401-5 GH, 200 Hawkins Drive, Iowa City, Iowa 52242, USA.
Department of Medicine, Division of Endocrinology and Metabolism, New York University Langone School of Medicine, New York, New York, 10016, USA.
Surg Oncol Clin N Am. 2020 Apr;29(2):145-163. doi: 10.1016/j.soc.2019.11.002.
To better understand developments in treatment of neuroendocrine tumors of the gastroenteropancreatic system, and the pivotal roles of native somatostatin and its long-acting analogues play in normal peptide regulation and neuropeptide excess associated with neuroendocrine tumors (NETs), this article delineates and defines distinct eras in the history and discovery of gastrointestinal endocrinology. We highlight the collaboration between academia and industry in basic science and the clinical research that advanced Lu-177-DOTATATE to approval as standard of care therapy for low-grade NETs. Examples of new radioisotopes and therapy compounds currently in development for diagnosis and therapy for high-grade NETs are also discussed.
为了更好地了解胃肠胰神经内分泌肿瘤治疗方面的进展，以及天然生长抑素及其长效类似物在正常肽调节和神经内分泌肿瘤（NETs）相关神经肽过度分泌中所起的关键作用，本文描述和定义了胃肠内分泌学历史和发现的不同时代。我们强调了学术界和工业界在基础科学和临床研究方面的合作，这些合作推动了 Lu-177-DOTATATE 被批准为低级别 NETs 的标准治疗方法。还讨论了目前正在开发用于高级别 NETs 诊断和治疗的新型放射性同位素和治疗化合物的实例。
