Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.
Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.
Brain Res Bull. 2020 May;158:116-121. doi: 10.1016/j.brainresbull.2020.03.005. Epub 2020 Mar 6.
Trace amines have been reported to be neuromodulators of monoaminergic systems. Trace amines receptor 5 (TAAR5) is expressed in several regions of mice central nervous system, such as amygdala, arcuate nucleus and ventromedial hypothalamus, but very limited information is available on its functional role. The purpose of this study is to examine the effect of TAAR5 agonist alpha-NETA on the generation of mismatch negativity (MMN) analogue in C57BL/6 mice. Event-related potentials have been recorded from awake mice in oddball paradigms before and after the alpha-NETA administration. Alpha-NETA has been found to decrease N40 MMN-like difference, which resulted from the increased response to standard stimuli. An opposite effect has been found for the P80 component: the amplitude increased in response both to standard and deviant stimuli. A significant increase in N40 peak latency after the alpha-NETA administration has been found. This may suggest a reduced speed of information processing similar to the increase in P50 and N100 components latencies in schizophrenia patients. These results provide new evidence for a role of TAAR5 in cognitive processes.
痕量胺被报道为单胺能系统的神经调节剂。痕量胺受体 5（TAAR5）在小鼠中枢神经系统的多个区域表达，如杏仁核、弓状核和腹内侧下丘脑，但关于其功能作用的信息非常有限。本研究的目的是研究 TAAR5 激动剂 alpha-NETA 对 C57BL/6 小鼠产生错配负波（MMN）类似物的影响。在 alpha-NETA 给药前后，通过清醒小鼠的偶发性范式记录事件相关电位。发现 alpha-NETA 降低了 N40 MMN 样差异，这是由于对标准刺激的反应增加所致。对于 P80 成分则发现了相反的效果：对标准和偏差刺激的反应都增加了振幅。在 alpha-NETA 给药后发现 N40 峰潜伏期显著增加。这可能表明信息处理速度降低，类似于精神分裂症患者 P50 和 N100 成分潜伏期的增加。这些结果为 TAAR5 在认知过程中的作用提供了新的证据。
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