TAAR5 激动剂 α-NETA 可引起小鼠运动障碍。
The TAAR5 agonist α-NETA causes dyskinesia in mice.
机构信息
Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.
Institute of Translational Biomedicine and Saint Petersburg University Hospital, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.
出版信息
Neurosci Lett. 2019 Jun 21;704:208-211. doi: 10.1016/j.neulet.2019.04.028. Epub 2019 Apr 12.
It is known that trace amine-associated receptor 5 (TAAR5) is expressed in various regions of the central nervous system. However, very limited information is available on the behavioral effects of TAAR5 activation and the TAAR5 functional role, in general. We studied the effect of TAAR5 agonist (2-(alpha-naphthoyl) ethyltrimethylammonium iodide) systemic administration on animal behavior. The study was performed on male C57BL/6 mice. It was observed that α-NETA in 10 mg/kg dose caused specific impairment of motor behavior, similar to the manifestations of tardive dyskinesia in humans. It can be assumed that trace amines and TAAR5 may be involved in the human tardive dyskinesia pathogenesis.
已知痕量胺相关受体 5（TAAR5）在中枢神经系统的各个区域表达。然而，关于 TAAR5 激活的行为效应和 TAAR5 的一般功能作用，信息非常有限。我们研究了 TAAR5 激动剂（2-（α-萘酰基）乙基三甲基氯化铵碘化物）全身给药对动物行为的影响。该研究在雄性 C57BL/6 小鼠上进行。观察到 10mg/kg 剂量的α-NETA 引起运动行为的特异性损伤，类似于人类迟发性运动障碍的表现。可以假设痕量胺和 TAAR5 可能参与人类迟发性运动障碍的发病机制。
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