Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.
Department of General Physiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.
Neurosci Lett. 2019 Nov 1;712:134470. doi: 10.1016/j.neulet.2019.134470. Epub 2019 Aug 30.
The potential contribution of trace amines (TA) to the pathophysiology of neuropsychiatric disorders makes it interesting to examine the effect of TA receptor ligands on schizophrenia biomarkers. We studied the effect of systemic administration of a putative Trace Amine-Associated Receptor 5 (TAAR5) agonist, alpha-NETA (2-(alpha-naphthoyl) ethyltrimethylammonium iodide), on the amplitude of the N40 event related potentials component and on the sensory gating (SG) index in C57BL/6 mice. It was found that low doses of alpha-NETA (2.5 mg/kg and 5 mg/kg) do not elicit a significant effect on the parameters of the N40 component and the SG index. However, the higher dose of alpha-NETA (10 mg/kg) induces a significant effect on the N40 component, but since a decrease in amplitude is observed on both the first and second stimuli in the pair, the SG index does not change. Thus, alpha-NETA administration causes a steady decrease in the N40 amplitude in response to both the first and second stimuli in the paired-click paradigm, and an increase in the N40 peak latency.
痕量胺（TA）对神经精神疾病病理生理学的潜在贡献使得研究 TA 受体配体对精神分裂症生物标志物的影响变得很有趣。我们研究了全身性给予假定的痕量胺相关受体 5（TAAR5）激动剂，α-NETA（2-（α-萘酰基）乙基三甲基铵碘化物）对 N40 事件相关电位成分的幅度和 C57BL/6 小鼠的感觉门控（SG）指数的影响。结果发现，低剂量的α-NETA（2.5mg/kg 和 5mg/kg）对 N40 成分和 SG 指数的参数没有明显影响。然而，较高剂量的α-NETA（10mg/kg）对 N40 成分产生显著影响，但由于在对刺激时观察到第一和第二个刺激的幅度都降低，因此 SG 指数没有变化。因此，α-NETA 给药导致在成对点击范式中对第一和第二个刺激的 N40 幅度持续降低，并增加 N40 峰潜伏期。
