Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, MP, India.
Methods Mol Biol. 2020;2118:165-174. doi: 10.1007/978-1-0716-0319-2_13.
The performance of polymeric nanomaterials relies greatly upon their properties which are intimately related to the methods of fabrication of their materials. Among various synthetic polymers the polymers of 2-hydroxyethyl methacrylate (PHEMA) maintains a prime position in the biomedical field due to their useful physicochemical properties and suitability for controlled drug delivery applications. Furthermore, the addition of iron oxide to PHEMA nanoparticles imparts superparamagnetism to the nanoparticles and expands the range of their uses to include magnetic drug targeting applications. Here we focus on three methods for preparation of PHEMA nanoparticles, one by suspension polymerization, a second by emulsion polymerization without the use of any surfactants, and the final one with the incorporation of iron oxide into PHEMA nanoparticles.
高分子纳米材料的性能在很大程度上依赖于其性质，而这些性质与材料的制备方法密切相关。在各种合成聚合物中，由于具有有用的物理化学性质和适合于控制药物释放应用，2-羟乙基甲基丙烯酸酯（PHEMA）聚合物在生物医学领域占据着首要地位。此外，将氧化铁添加到 PHEMA 纳米粒子中会赋予纳米粒子超顺磁性，并将其用途扩展到包括磁性药物靶向应用。在这里，我们重点介绍了三种制备 PHEMA 纳米粒子的方法，一种是通过悬浮聚合，另一种是通过乳液聚合而不使用任何表面活性剂，最后一种是将氧化铁掺入 PHEMA 纳米粒子中。
