Dong Jiaqi, Carpinone Paul L, Pyrgiotakis Georgios, Demokritou Philip, Moudgil Brij M
Center for Particulate and Surfactant Systems, Department of Materials Science and Engineering, University of Florida, USA.
HSPH-NIEHS Nanosafety Center, School of Public Health, Harvard University, USA.
Kona. 2020 Jan 10;37:224-232. doi: 10.14356/kona.2020011. Epub 2020 Feb 29.
Gold nanoparticles (AuNPs) exhibit unique size-dependent physiochemical properties that make them attractive for a wide range of applications. However, the large-scale availability of precision AuNPs has been minimal. Not only must the required nanoparticles be of precise size and morphology, but they must also be of exceedingly narrow size distribution to yield accurate and reliable performance. The present study aims to synthesize precision AuNPs and to assess the advantages and limitations of the Turkevich method-one of the common chemical synthesis technique. Colloidal AuNPs from 15 nm to 50 nm in diameter were synthesized using the Turkevich method. The effect of the molar ratio of the reagent mixture (trisodium citrate to gold chloride), the scaled-up batch size, the initial gold chloride concentration, and the reaction temperature was studied. The morphology, optical property, surface chemistry, and chemical composition of AuNPs were thoroughly characterized. It was determined that the as-synthesized AuNPs between 15 nm and 30 nm exhibit well-defined size and shape, and narrow size distribution ( < 0.20). However, the AuNPs became more polydispersed and less spherical in shape as the particle size increased.
金纳米颗粒（AuNPs）展现出独特的尺寸依赖性物理化学性质，这使其在广泛的应用中具有吸引力。然而，精确的金纳米颗粒的大规模可得性一直很低。所需的纳米颗粒不仅必须具有精确的尺寸和形态，而且其尺寸分布还必须极其狭窄，以产生准确可靠的性能。本研究旨在合成精确的金纳米颗粒，并评估常用化学合成技术之一的Turkevich方法的优缺点。使用Turkevich方法合成了直径为15纳米至50纳米的胶体金纳米颗粒。研究了试剂混合物（柠檬酸钠与氯化金）的摩尔比、放大的批量大小、初始氯化金浓度和反应温度的影响。对金纳米颗粒的形态、光学性质、表面化学和化学成分进行了全面表征。结果表明，合成的15纳米至30纳米的金纳米颗粒具有明确的尺寸和形状，且尺寸分布狭窄（<0.20）。然而，随着粒径的增加，金纳米颗粒的多分散性增强，形状也变得不太规则。
