Kobrin V I, Alabovskiĭ V V, Alipov N N, Oleĭnikov O D
Fiziol Zh SSSR Im I M Sechenova. 1988 Sep;74(9):1257-62.
The transmembrane potentials of the cells of the ventricle contractile myocardium of the rat and frog isolated hearts were studied as well as the strength of the ventricle contraction under the effect of a decrease (to 30 mM) or increase (up to 200 mM) in the sodium chloride concentration in the perfusate. The decrease led to a fibrillation of ventricles, 80-85% of contractile cells generating a high-frequency activity, 12-15% preserving the same AP and 3-5% having completely lost the excitability. The increase only affects the transmembrane potentials of ischemized myocardium. The decrease in the sodium concentration led to an augmentation of the contraction strength through the sodium-calcium exchange mechanism.
研究了大鼠和青蛙离体心脏心室收缩性心肌细胞的跨膜电位，以及在灌注液中氯化钠浓度降低（至30 mM）或升高（至200 mM）的情况下心室收缩的强度。氯化钠浓度降低导致心室纤颤，80 - 85%的收缩细胞产生高频活动，12 - 15%的细胞保持相同的动作电位，3 - 5%的细胞完全丧失兴奋性。氯化钠浓度升高仅影响缺血心肌的跨膜电位。钠浓度降低通过钠钙交换机制导致收缩强度增强。
