The Ministry of Education Key Laboratory, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
School of Medicine, Tsinghua University, Beijing, China.
Front Immunol. 2020 Feb 21;11:282. doi: 10.3389/fimmu.2020.00282. eCollection 2020.
The emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance. Dysbiosis of gut microbiota has been shown to be related to various alterations of the immune system. This review focuses on the reciprocal relationship between gut microbiota and innate immunity compartment, with emphasis on gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes. From a clinical perspective, the review gives a possible explanation of how the "gut microbiota-innate immunity" axis might contribute to the pathogenesis of autoimmune diseases like rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus.
肠道微生物群有助于局部黏膜稳态的新兴概念激发了对其在免疫学中特定作用的研究。肠道微生物群主要负责维持宿主防御和免疫耐受之间的平衡。肠道微生物群的失调已被证明与免疫系统的各种改变有关。本综述重点关注肠道微生物群与固有免疫区室之间的相互关系，强调肠道相关淋巴组织、固有淋巴细胞和吞噬细胞。从临床角度来看，该综述对“肠道微生物群-固有免疫”轴如何有助于类风湿关节炎、脊柱关节炎和系统性红斑狼疮等自身免疫性疾病的发病机制提供了一种可能的解释。
