Garruti Gabriella, De Fazio Michele, Capuano Palma, Martinez Gennaro, Rotelli Maria T, Puglisi Francesco, Palasciano Nicola, Giorgino Francesco
Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124, Bari, Italy.
Department of Emergency and Organ Transplantation, Section of General Surgery and Liver Transplantation, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124, Bari, Italy.
Ann Med Surg (Lond). 2020 Feb 25;52:10-15. doi: 10.1016/j.amsu.2020.02.005. eCollection 2020 Apr.
Adiponectin and Resistin correlate with insulin sensitivity and cardiovascular risk, respectively. This study aimed to identify lifestyle factors that modulate changes in Adiponectin and Resistin levels after gastric banding positioning (LapGB).
Before (T0), 3 months (T3), 6 months (T6), and 12 months (T12) after LapGB, serum Adiponectin and Resistin levels were evaluated in a single-centre prospective study including a cohort of 27 non-diabetic obese subjects (S-Ob, BMI ≥35 kg/m). After surgery, a dietitian checked the adherence of S-Ob to an Apulian hypocaloric diet (aphypoD)/physical activity (phA) and, according to their high or low compliance to aphypoD/phA, S-Ob were included in group 1 (n = 14) or 2 (n = 13) respectively. Serum Adiponectin and Resistin were also measured in 10 healthy controls.
At baseline, Resistin levels were significantly higher and Adiponectin levels significantly lower in S-Ob than in controls. After surgery, group 1 showed a 50.2% excess weight loss (%EWL), significantly decreased Resistin levels at T12 and increased Adiponectin levels at both T6 and T12 as compared with baseline. Group 2 showed 24.6 %EWL at T12, decreased Adiponectin levels at T6 and T12 as compared with baseline, but unaltered Resistin levels. After surgery, group 1 followed aphypoD/phA, while group 2 did not.
LapGB fails to improve cardiovascular risk markers (Resistin) in S-Ob not improving lifestyle. Future studies might investigate these findings in a larger cohort and display whether aphypoD is more effective than other dietary intervention on cardiovascular risk in subjects undergoing LapGB or other Bariatric procedures.
脂联素和抵抗素分别与胰岛素敏感性和心血管风险相关。本研究旨在确定影响胃束带术（LapGB）后脂联素和抵抗素水平变化的生活方式因素。
在一项单中心前瞻性研究中，对27名非糖尿病肥胖受试者（S-Ob，BMI≥35kg/m²）队列在LapGB术前（T0）、术后3个月（T3）、6个月（T6）和12个月（T12）时评估血清脂联素和抵抗素水平。术后，营养师检查S-Ob对阿普利亚低热量饮食（aphypoD）/体育活动（phA）的依从性，并根据他们对aphypoD/phA的高或低依从性，将S-Ob分别纳入第1组（n = 14）或第2组（n = 13）。还对10名健康对照者测量了血清脂联素和抵抗素。
在基线时，S-Ob组的抵抗素水平显著高于对照组，脂联素水平显著低于对照组。术后，第1组体重减轻了50.2%（%EWL），与基线相比，T12时抵抗素水平显著降低，T6和T12时脂联素水平均升高。第2组在T12时体重减轻了24.6%EWL，与基线相比，T6和T12时脂联素水平降低，但抵抗素水平未改变。术后，第1组遵循aphypoD/phA，而第2组没有。
对于未改善生活方式的S-Ob，LapGB未能改善心血管风险标志物（抵抗素）。未来的研究可能会在更大的队列中研究这些发现，并展示aphypoD在接受LapGB或其他减肥手术的受试者中对心血管风险是否比其他饮食干预更有效。
