Li Qiling, Wang Qi, Xu Wei, Ma Yamin, Wang Qing, Eatman Danita, You Shaojin, Zou Jin, Champion James, Zhao Lanbo, Cui Ye, Li Wenzhi, Deng Yangyang, Ma Li, Wu Biao, Wang Guangdi, Zhang Xiaodong, Wang Qingwei, Bayorh Mohamed A, Song Qing
Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Cardiovascular Research Institute and Department of Medicine, Morehouse School of Medicine, Atlanta, GA, United States.
Front Cell Dev Biol. 2020 Feb 20;8:18. doi: 10.3389/fcell.2020.00018. eCollection 2020.
Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found to be the strongest factor associated with obesity. Here we show that chronic elevation of human CRP at baseline level causes the obesity. The obesity phenotype is confirmed by whole-body magnetic resonance imaging (MRI), in which the total fat mass is 6- to 9- fold higher in the CRP rats than the control rats. Univariate linear regression analysis showed different growth rates between the CRP rats and the control rats, and that the difference appears around 11 weeks old, indicating that they developed adult-onset obesity. We also found that chronic elevation of CRP can prime molecular changes broadly in the innate immune system, energy expenditure systems, thyroid hormones, apolipoproteins, and gut flora. Our data established a causal role of CRP elevation in the development of adult-onset obesity.
肥胖的特征是低度慢性炎症。作为对炎症和感染的一种急性期反应物，人们发现C反应蛋白（CRP）是与肥胖相关的最强因素。在此我们表明，人CRP在基线水平的慢性升高会导致肥胖。肥胖表型通过全身磁共振成像（MRI）得到证实，其中CRP大鼠的总脂肪量比对照大鼠高6至9倍。单变量线性回归分析显示CRP大鼠和对照大鼠之间的生长速率不同，且这种差异在约11周龄时出现，表明它们患上了成年期起病的肥胖症。我们还发现，CRP的慢性升高可广泛引发先天性免疫系统、能量消耗系统、甲状腺激素、载脂蛋白和肠道菌群中的分子变化。我们的数据确立了CRP升高在成年期起病肥胖症发展中的因果作用。
