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一项考察患者对用于注射培塞丽珠单抗的可重复使用电子注射装置 Ava®的偏好和满意度的初步研究。

A pilot study examining patient preference and satisfaction for ava®, a reusable electronic injection device to administer certolizumab pegol.

机构信息

Sint Maartenskliniek, Nijmegen, Netherlands.

Radboud University Medical Center, Nijmegen, The Netherlands.

出版信息

Expert Opin Drug Deliv. 2020 May;17(5):705-711. doi: 10.1080/17425247.2020.1736552. Epub 2020 Mar 23.

Abstract

: Anti-tumor necrosis factor (anti-TNF) adherence is suboptimal. ava®, a reusable electromechanical self-injection device (e-Device) developed for certolizumab pegol (CZP) administration, aims to overcome some barriers to increase adherence. This study evaluates patient experience of the e-Device and its training materials and determines patient device preference.: CZP-treated patients were recruited from the Netherlands, Denmark and Sweden. Patients completed a pre-injection Assessment of Self-Injection (ASI) questionnaire investigating self-injection perception. After training, patients administered 3 consecutive self-injections using the e-Device, patient experience of each was assessed using the post-injection ASI. An additional questionnaire evaluated training materials. After Injection 3, patients indicated their preference: the e-Device or their previous device.: 59 patients participated; most rated the e-Device highly for satisfaction, self-confidence and ease of use. The (negative) feelings and pain and skin reactions domains had low ratings. Post-injection ASI domain scores were similar following each of the 3 e-Device injections. Training materials were rated highly (video: 8.4/10; step-by-step guide: 8.4/10). 57.1% (32/56) patients preferred the e-Device over their previous self-injection device.: Patients were satisfied with the e-Device and most preferred it over other self-injection devices. By improving patient experience, the e-Device may help increase medication adherence.

摘要

: 抗肿瘤坏死因子(anti-TNF)的依从性并不理想。ava®是一种为 certolizumab pegol(CZP)给药开发的可重复使用的机电自注设备(e-Device),旨在克服一些增加依从性的障碍。本研究评估了患者对 e-Device 及其培训材料的体验,并确定了患者对设备的偏好。

: 在荷兰、丹麦和瑞典招募接受 CZP 治疗的患者。患者完成了一项关于自我注射感知的预注射自我评估(ASI)问卷。在接受培训后,患者使用 e-Device 连续进行 3 次自我注射,使用注射后 ASI 评估每次注射的患者体验。另外一份问卷评估了培训材料。在注射 3 后,患者表明他们的偏好:e-Device 或他们之前的设备。

: 59 名患者参与了研究;大多数患者对设备的满意度、自信心和易用性给予高度评价。(负面)感觉、疼痛和皮肤反应等领域的评分较低。在使用 e-Device 进行的 3 次注射后,注射后 ASI 域评分相似。培训材料的评分很高(视频:8.4/10;分步指南:8.4/10)。57.1%(32/56)的患者更喜欢 e-Device 而不是他们之前的自我注射设备。

: 患者对 e-Device 感到满意,大多数人更喜欢 e-Device 而不是其他自我注射设备。通过改善患者体验,e-Device 可能有助于提高药物依从性。

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