葛根素通过抑制单核细胞趋化蛋白-1（MCP-1）的产生来抑制破骨细胞前体的迁移和破骨细胞生成。
Puerarin inhibits the migration of osteoclast precursors and osteoclastogenesis by inhibiting MCP-1 production.
作者信息
Lin Sanfu, Ke Dianshan, Lin Yinquan, Fu Xiaomin, Yu Yunlong
机构信息
Department of Orthopedics, The Second Affiliated Hospital of Fujian Medical University , Quanzhou, Fujian, China.
Department of Orthopedics, The People's Hospital of JiangMen , Jiangmen, Guangdong, China.
出版信息
Biosci Biotechnol Biochem. 2020 Jul;84(7):1455-1459. doi: 10.1080/09168451.2020.1738912. Epub 2020 Mar 10.
Puerarin inhibits osteoclastogenesis and cells migration. This study aims to explore whether puerarin prevents osteoclastogenesis by inhibiting osteoclast precursors (OCPs) migration. The results showed that puerarin reduced MCP-1 production in OCPs, while inhibiting OCPs migration based on MCP-1. Puerarin reversed MCP-1-promoted osteoclastogenesis. CCR2 overexpression didn't increase osteoclastogenesis with puerarin. Therefore, puerarin prevents OCPs migration by reducing MCP-1, whereby inhibiting osteoclastogenesis.
葛根素抑制破骨细胞生成和细胞迁移。本研究旨在探讨葛根素是否通过抑制破骨细胞前体（OCPs）迁移来预防破骨细胞生成。结果表明，葛根素降低了OCPs中MCP-1的产生，同时基于MCP-1抑制OCPs迁移。葛根素逆转了MCP-1促进的破骨细胞生成。CCR2过表达在有葛根素的情况下并未增加破骨细胞生成。因此，葛根素通过减少MCP-1来阻止OCPs迁移，从而抑制破骨细胞生成。
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