Kou Baixin, Meng Lingkun, Zhao Mengya, Wang Haidong, Lu Chunyang, Yan Mingming, Li Guangzhe
School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, China.
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China.
Front Pharmacol. 2025 Jul 10;16:1578472. doi: 10.3389/fphar.2025.1578472. eCollection 2025.
(Willd.) Ohwi, a perennial vine native to China, has significant medicinal and edible value. Its roots are used as medicine and are known as kudzu (Chinese: ) and were first recorded in . In addition, its roots and powder can be made into food.
To integrate information on the source of (PL), summarize the evolution of its medicinal and edible value, and generalize its chemical composition, biosynthetic pathways, metabolism, and biological activity.
A comprehensive literature search (1975-2025) was conducted across ScienceDirect, Google Scholar, PubMed, Web of Science, CNKI, WFO (www.worldfloraonline.org), MPNS (https://mpsn.kew.org), Changchun University of Chinese Medicine Library collections, and SciFinder. Ancient applications were validated through analysis of classic Chinese medical literature.
PL is predominantly found in Asia, Europe, and America, with significant populations in China's Zhejiang, Jiangxi, Jiangsu, Guangdong, and Guangxi provinces. The plant comprises flavonoids, triterpenoids, and coumarins, including isoflavonoids like daidzein and puerarin, which are synthesized via diverse pathways. Metabolites produced from liver or intestinal reactions are crucial to PL's effectiveness. Key components include puerarin, daidzein, genistein, biochanin A, and formononetin. In China, PL is incredibly versatile, being used in a wide range of foods, teas, preservatives, dairy products,
Its extensive biological activities benefit the human body, with particular emphasis on liver protection, anti-osteoporosis, and anti-diabetic effects. These attributes highlight the potential for developing health foods, revealing PL's promising prospects in the pharmaceuticals and nutritional healthcare industries.
(Willd.)Ohwi是一种原产于中国的多年生藤本植物,具有重要的药用和食用价值。其根可入药,被称为葛根(中文: ),最早记载于 。此外,其根和粉可制成食品。
整合葛根(PL)的来源信息,总结其药用和食用价值的演变,并概括其化学成分、生物合成途径、代谢和生物活性。
在ScienceDirect、谷歌学术、PubMed、科学网、中国知网、世界植物在线(www.worldfloraonline.org)、世界植物名录(https://mpsn.kew.org)、长春中医药大学图书馆馆藏以及SciFinder上进行了全面的文献检索(1975 - 2025年)。通过分析中国古典医学文献验证古代应用。
PL主要分布在亚洲、欧洲和美洲,在中国浙江、江西、江苏、广东和广西等省份有大量分布。该植物含有黄酮类、三萜类和香豆素类化合物,包括大豆苷元和葛根素等异黄酮类化合物,它们通过多种途径合成。肝脏或肠道反应产生的代谢产物对PL的功效至关重要。关键成分包括葛根素、大豆苷元、染料木素、鹰嘴豆芽素A和芒柄花素。在中国,PL用途广泛,被用于多种食品、茶、防腐剂、乳制品中。
其广泛的生物活性对人体有益,尤其在肝脏保护、抗骨质疏松和抗糖尿病方面效果显著。这些特性凸显了开发健康食品的潜力,揭示了PL在制药和营养保健行业的广阔前景。