Department of Developmental and Cell Biology, 2208 Natural Sciences I, University of California, Irvine, CA 92697-2300, USA.
Curr Biol. 2020 Mar 9;30(5):R222-R224. doi: 10.1016/j.cub.2020.01.039.
MEK, a central component of the Ras/MAPK cascade, is mutated in human tumors and developmental disorders. Recent studies are beginning to dissect the mechanisms that make these MEK mutants hyperactive.
MEK 是 Ras/MAPK 级联反应的核心组成部分，在人类肿瘤和发育障碍中发生突变。最近的研究开始剖析使这些 MEK 突变体过度活跃的机制。
