Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Korea.
Department of Pathology, Dong-A University College of Medicine, Busan 49201, Korea.
Int J Environ Res Public Health. 2020 Mar 6;17(5):1726. doi: 10.3390/ijerph17051726.
(1) Background: Cervical cancer is one of the most common cancers in Korean women. This study was performed to discover the utility of HPV (Human Papillomavirus) testing in screening of cervical lesions and to provide the prevalence of HPV and the genotype distribution in a single center of Korea. (2) Methods: A total of 15,141 women who underwent both HPV testing and cervical cytology were enrolled in this retrospective medical record review study. (3) Results: HPV testing showed higher sensitivity than cytology for the detection of histological high-grade squamous lesions. Furthermore, the sensitivity and specificity of HPV testing varied depending on the method used. The BD Onclarity™ HPV assay had higher sensitivity (90%) than the MyHPV CHIP™ kit (all types of HPV: 82%; high-risk HPV: 76%) for high-grade squamous lesions. A combination of MyHPV CHIP™ and cytology detected 90.9% (30/33) of histological high-grade squamous lesions. A combination of BD Onclarity™ HPV assay and cytology detected 96.55% (84/87) of histological high-grade squamous lesions. In addition, HPV prevalence and genotype distribution were different depending on the HPV testing method used. (4) Conclusion: HPV testing showed higher sensitivity than cytology, but the sensitivity and specificity of HPV testing had variation depending on the method used.
（1）背景：宫颈癌是韩国女性最常见的癌症之一。本研究旨在探讨 HPV（人乳头瘤病毒）检测在宫颈病变筛查中的应用价值，并提供韩国单一中心 HPV 的流行率及基因型分布情况。（2）方法：本回顾性病历研究共纳入 15141 名同时接受 HPV 检测和宫颈细胞学检查的女性。（3）结果：HPV 检测在检测组织学高级别鳞状病变方面的敏感性高于细胞学检查。此外，HPV 检测的敏感性和特异性因检测方法的不同而有所差异。BD Onclarity™ HPV 检测（所有 HPV 类型：82%；高危型 HPV：76%）对高级别鳞状病变的敏感性高于 MyHPV CHIP™ 试剂盒（90%）。MyHPV CHIP™ 试剂盒联合细胞学检查检测出 30/33 例组织学高级别鳞状病变。BD Onclarity™ HPV 检测联合细胞学检查检测出 84/87 例组织学高级别鳞状病变。此外，HPV 的流行率和基因型分布因 HPV 检测方法的不同而有所差异。（4）结论：HPV 检测的敏感性高于细胞学检查，但 HPV 检测的敏感性和特异性因检测方法的不同而有所差异。
