乙酰胆碱酯酶：神经退行性疾病和《化学武器公约》的“枢纽”。
Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention.
机构信息
Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil.
Walter Mors Institute of Research on Natural Products (IPPN), Federal University of Rio de Janeiro (UFRJ), CCS, Bloco H, Rio de Janeiro 21941-902, Brazil.
出版信息
Biomolecules. 2020 Mar 7;10(3):414. doi: 10.3390/biom10030414.
This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer's disease, or as a warfare method due to the action of nerve agents. The chemical concepts related to the irreversible inhibition of AChE, its reactivation, and aging are discussed, along with a relationship to the current international legislation on chemical weapons.
本文描述了乙酰胆碱酯酶（AChE），一种参与副交感神经传递的酶，其活性，以及其抑制如何在药理学上有益于治疗由阿尔茨海默病引起的痴呆，或由于神经毒剂的作用而作为一种战争方法。讨论了与 AChE 的不可逆抑制、其重激活和老化相关的化学概念，以及与当前关于化学武器的国际立法的关系。
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