• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

乙酰胆碱酯酶：神经退行性疾病和《化学武器公约》的“枢纽”。

Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention.

机构信息

Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil.

Walter Mors Institute of Research on Natural Products (IPPN), Federal University of Rio de Janeiro (UFRJ), CCS, Bloco H, Rio de Janeiro 21941-902, Brazil.

出版信息

Biomolecules. 2020 Mar 7;10(3):414. doi: 10.3390/biom10030414.

DOI:10.3390/biom10030414
PMID:32155996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7175162/
Abstract

This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer's disease, or as a warfare method due to the action of nerve agents. The chemical concepts related to the irreversible inhibition of AChE, its reactivation, and aging are discussed, along with a relationship to the current international legislation on chemical weapons.

摘要

本文描述了乙酰胆碱酯酶（AChE），一种参与副交感神经传递的酶，其活性，以及其抑制如何在药理学上有益于治疗由阿尔茨海默病引起的痴呆，或由于神经毒剂的作用而作为一种战争方法。讨论了与 AChE 的不可逆抑制、其重激活和老化相关的化学概念，以及与当前关于化学武器的国际立法的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/eeb9f3cfe2ac/biomolecules-10-00414-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/8062d983aebd/biomolecules-10-00414-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/3d256843d1e7/biomolecules-10-00414-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/88aae59422a3/biomolecules-10-00414-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/dcf5cf98f832/biomolecules-10-00414-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/000f5cf71e04/biomolecules-10-00414-ch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/e526cdfe567a/biomolecules-10-00414-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/08dfd711e9f7/biomolecules-10-00414-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/3143f21132ff/biomolecules-10-00414-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/b5d8ef752ba1/biomolecules-10-00414-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/19e32e2cf459/biomolecules-10-00414-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/83dae7a30d1e/biomolecules-10-00414-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/f472c22728f3/biomolecules-10-00414-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/2b3d0b6fca7f/biomolecules-10-00414-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/82e152a72fe1/biomolecules-10-00414-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/9020297d54ef/biomolecules-10-00414-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/0d1d7a30d1e3/biomolecules-10-00414-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/af7c22b4286d/biomolecules-10-00414-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/906a2a1ee1f2/biomolecules-10-00414-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/75a46d5617a7/biomolecules-10-00414-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/0477b9ecb65e/biomolecules-10-00414-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/1b93b0b2ef0d/biomolecules-10-00414-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/eeb9f3cfe2ac/biomolecules-10-00414-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/8062d983aebd/biomolecules-10-00414-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/3d256843d1e7/biomolecules-10-00414-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/88aae59422a3/biomolecules-10-00414-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/dcf5cf98f832/biomolecules-10-00414-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/000f5cf71e04/biomolecules-10-00414-ch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/e526cdfe567a/biomolecules-10-00414-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/08dfd711e9f7/biomolecules-10-00414-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/3143f21132ff/biomolecules-10-00414-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/b5d8ef752ba1/biomolecules-10-00414-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/19e32e2cf459/biomolecules-10-00414-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/83dae7a30d1e/biomolecules-10-00414-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/f472c22728f3/biomolecules-10-00414-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/2b3d0b6fca7f/biomolecules-10-00414-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/82e152a72fe1/biomolecules-10-00414-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/9020297d54ef/biomolecules-10-00414-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/0d1d7a30d1e3/biomolecules-10-00414-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/af7c22b4286d/biomolecules-10-00414-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/906a2a1ee1f2/biomolecules-10-00414-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/75a46d5617a7/biomolecules-10-00414-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/0477b9ecb65e/biomolecules-10-00414-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/1b93b0b2ef0d/biomolecules-10-00414-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95cd/7175162/eeb9f3cfe2ac/biomolecules-10-00414-g015.jpg

相似文献

1
Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention.乙酰胆碱酯酶：神经退行性疾病和《化学武器公约》的“枢纽”。
Biomolecules. 2020 Mar 7;10(3):414. doi: 10.3390/biom10030414.
2
TV 3326 for Alzheimer's dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer's-like neuropathology.用于治疗阿尔茨海默病痴呆症的TV 3326：一种新型多模式胆碱酯酶和单胺氧化酶抑制剂，可减轻阿尔茨海默病样神经病理学变化
J Pharm Pharmacol. 2020 Aug;72(8):1001-1012. doi: 10.1111/jphp.13244. Epub 2020 Mar 9.
3
Cholinesterases and the fine line between poison and remedy.胆碱酯酶与毒与药之间的微妙界限。
Biochem Pharmacol. 2018 Jul;153:205-216. doi: 10.1016/j.bcp.2018.01.044. Epub 2018 Jan 31.
4
A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.香豆素类化合物作为乙酰胆碱酯酶抑制剂治疗阿尔茨海默病的研究进展。
Bioorg Med Chem. 2012 Feb 1;20(3):1175-80. doi: 10.1016/j.bmc.2011.12.042. Epub 2011 Dec 30.
5
Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer's Disease: Nexus of Cholinergic and Nerve Growth Factor Dysfunction.乙酰胆碱酯酶抑制剂在阿尔茨海默病中的神经退行性保护作用：胆碱能和神经生长因子功能障碍的关系。
Curr Alzheimer Res. 2021;18(13):1010-1022. doi: 10.2174/1567205018666211215150547.
6
Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs.乙酰胆碱酯酶活性调节剂：从阿尔茨海默病到抗癌药物
Curr Med Chem. 2017;24(30):3283-3309. doi: 10.2174/0929867324666170705123509.
7
4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.4,6-二苯基嘧啶衍生物作为单胺氧化酶和乙酰胆碱酯酶的双重抑制剂用于治疗阿尔茨海默病。
ACS Chem Neurosci. 2019 Jan 16;10(1):252-265. doi: 10.1021/acschemneuro.8b00220. Epub 2018 Oct 22.
8
[Alzheimer disease. Pseudo-irreversible AChE inhibition with rivastigmine].[阿尔茨海默病。卡巴拉汀的假性不可逆性乙酰胆碱酯酶抑制作用]
Med Monatsschr Pharm. 1998 Aug;21(8):248-9.
9
Identification of molecular descriptors for design of novel Isoalloxazine derivatives as potential Acetylcholinesterase inhibitors against Alzheimer's disease.鉴定用于设计新型异咯嗪衍生物的分子描述符，这些衍生物作为潜在的抗阿尔茨海默病乙酰胆碱酯酶抑制剂。
J Biomol Struct Dyn. 2017 Jun;35(8):1729-1742. doi: 10.1080/07391102.2016.1192485. Epub 2016 Jul 28.
10
Acetylcholinesterase and its inhibition in Alzheimer disease.乙酰胆碱酯酶及其在阿尔茨海默病中的抑制作用
Clin Neuropharmacol. 2004 May-Jun;27(3):141-9. doi: 10.1097/00002826-200405000-00011.

引用本文的文献

1
Ginsenoside Rg1 Promotes the Survival, Proliferation, and Differentiation of Senescent Neural Stem Cells Induced by D-galactose.人参皂苷Rg1促进D-半乳糖诱导的衰老神经干细胞的存活、增殖和分化。
Actas Esp Psiquiatr. 2025 Jan;53(1):49-61. doi: 10.62641/aep.v53i1.1812.
2
Enzyme ChE, cholinergic therapy and molecular docking: Significant considerations and future perspectives.酶 ChE、胆碱能治疗和分子对接：重要考虑因素和未来展望。
Int J Immunopathol Pharmacol. 2024 Jan-Dec;38:3946320241289013. doi: 10.1177/03946320241289013.
3
scL-2PAM: A Novel Countermeasure That Ameliorates Neuroinflammation and Neuronal Losses in Mice Exposed to an Anticholinesterase Organophosphate.

本文引用的文献

1
The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer's disease and vascular dementia: focusing on fluoxetine with long follow-up periods.选择性5-羟色胺再摄取抑制剂对阿尔茨海默病和血管性痴呆患者认知功能的影响：聚焦于长期随访的氟西汀
Signal Transduct Target Ther. 2019 Aug 30;4:30. doi: 10.1038/s41392-019-0064-7. eCollection 2019.
2
In Vitro Evaluation of Neutral Aryloximes as Reactivators for Acetylcholinesterase Inhibited by Paraoxon.体外评价芳氧基肟类化合物作为对氧磷抑制的乙酰胆碱酯酶的重活化剂。
Biomolecules. 2019 Oct 8;9(10):583. doi: 10.3390/biom9100583.
3
PROTACs- a game-changing technology.
scL-2PAM：一种新型解毒剂，可改善暴露于抗胆碱酯酶有机磷化合物的小鼠中的神经炎症和神经元丢失。
Int J Mol Sci. 2024 Jul 9;25(14):7539. doi: 10.3390/ijms25147539.
4
Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate.合成及临床应用肟类化合物对 A-230 神经毒剂类似物抑制的乙酰胆碱酯酶模型复能作用的体外评价
Arch Toxicol. 2024 Oct;98(10):3397-3407. doi: 10.1007/s00204-024-03821-3. Epub 2024 Jul 14.
5
Research Progress in the Degradation of Chemical Warfare Agent Simulants Using Metal-Organic Frameworks.金属有机框架材料用于降解化学战剂模拟物的研究进展
Nanomaterials (Basel). 2024 Jun 28;14(13):1108. doi: 10.3390/nano14131108.
6
Neuroprotective effects of cordycepin inhibit glutamate-induced apoptosis in hippocampal neurons.虫草素的神经保护作用抑制了海马神经元中谷氨酸诱导的细胞凋亡。
Cell Stress Chaperones. 2024 Feb;29(1):10-20. doi: 10.1016/j.cstres.2024.01.001. Epub 2024 Jan 12.
7
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti-seizure agents.桥环双环化合物：理解一种新型化合物类别作为潜在的抗癫痫药物。
Epilepsia. 2023 Nov;64(11):2958-2967. doi: 10.1111/epi.17769. Epub 2023 Sep 19.
8
Physiological ischemic training improves cardiac function through the attenuation of cardiomyocyte apoptosis and the activation of the vagus nerve in chronic heart failure.生理性缺血训练通过减轻慢性心力衰竭时心肌细胞凋亡和激活迷走神经来改善心脏功能。
Front Neurosci. 2023 Apr 20;17:1174455. doi: 10.3389/fnins.2023.1174455. eCollection 2023.
9
Exposure of adult zebrafish (Danio rerio) to SARS-CoV-2 at predicted environmentally relevant concentrations: Outspreading warns about ecotoxicological risks to freshwater fish.成年斑马鱼（Danio rerio）在预测的环境相关浓度下暴露于 SARS-CoV-2 ：扩散警告对淡水鱼类的生态毒理学风险。
Sci Total Environ. 2023 Jul 1;880:163269. doi: 10.1016/j.scitotenv.2023.163269. Epub 2023 Apr 5.
10
Evaluation of Activity of Sesquiterpene Lactones and Chicory Extracts as Acetylcholinesterase Inhibitors Assayed in Calorimetric and Docking Simulation Studies.评价倍半萜内酯和菊苣提取物作为乙酰胆碱酯酶抑制剂的活性：在量热和对接模拟研究中的测定。
Nutrients. 2022 Sep 2;14(17):3633. doi: 10.3390/nu14173633.
PROTACs——一项颠覆性技术。
Expert Opin Drug Discov. 2019 Dec;14(12):1255-1268. doi: 10.1080/17460441.2019.1659242. Epub 2019 Sep 20.
4
Selective serotonin reuptake inhibitors and Alzheimer's disease.选择性5-羟色胺再摄取抑制剂与阿尔茨海默病
Neural Regen Res. 2020 Jan;15(1):41-46. doi: 10.4103/1673-5374.264445.
5
Lessons that can be learnt from the failure of verubecestat in Alzheimer's disease.从阿尔茨海默病中维鲁贝司他的失败中吸取的教训。
Expert Opin Pharmacother. 2019 Dec;20(17):2095-2099. doi: 10.1080/14656566.2019.1654998. Epub 2019 Aug 18.
6
Alzheimer's disease drug development pipeline: 2019.2019年阿尔茨海默病药物研发进程
Alzheimers Dement (N Y). 2019 Jul 9;5:272-293. doi: 10.1016/j.trci.2019.05.008. eCollection 2019.
7
In vitro degradation of β-amyloid fibrils by microbial keratinase.微生物角蛋白酶对β-淀粉样蛋白原纤维的体外降解
Alzheimers Dement (N Y). 2019 May 16;5:154-163. doi: 10.1016/j.trci.2019.03.003. eCollection 2019.
8
Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate.中性芳氧肟的合成及体外评价作为电鳗乙酰胆碱酯酶的重活化剂，其被 NEMP（一种 VX 类似物）抑制。
Chem Biol Interact. 2019 Aug 25;309:108682. doi: 10.1016/j.cbi.2019.05.048. Epub 2019 Jun 1.
9
Depression in Alzheimer's Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors?阿尔茨海默病中的抑郁：选择性5-羟色胺再摄取抑制剂的另一种作用？
J Alzheimers Dis. 2019;69(3):651-661. doi: 10.3233/JAD-180780.
10
Treatment of Alzheimer's by PROTAC-Tau Protein Degradation.通过PROTAC介导的tau蛋白降解治疗阿尔茨海默病
ACS Med Chem Lett. 2019 Mar 12;10(5):699-700. doi: 10.1021/acsmedchemlett.9b00083. eCollection 2019 May 9.