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2017 年 11 月瑞典哈兰省暴发肠炎,突显肠侵袭性大肠杆菌的诊断和流行病学挑战。

Outbreak of gastroenteritis highlighting the diagnostic and epidemiological challenges of enteroinvasive , County of Halland, Sweden, November 2017.

机构信息

Public Health Agency of Sweden, Solna, Sweden.

European Public Health Microbiology Training Programme (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.

出版信息

Euro Surveill. 2020 Mar;25(9). doi: 10.2807/1560-7917.ES.2020.25.9.1900466.

Abstract

An outbreak of gastroenteritis with 83 cases occurred at a conference venue in November 2017 in Halland County, Sweden. Stool samples from two venue visitors and a symptomatic secondary case attributed to household transmission were PCR-positive for the gene, a target found in both spp. and enteroinvasive (EIEC). EIEC was isolated from stool samples and whole genome sequencing analysis confirmed EIEC O96:H19 to be the aetiological agent. A cohort study was conducted among venue attendees and employees and the findings implicated contaminated leafy greens as the vehicle of infection, however, no microbiological evidence could support the study results. Here, we report the investigation into the first recorded EIEC outbreak in Sweden and illustrate the challenges associated with the differential laboratory diagnostics of /EIEC in an outbreak setting.

摘要

2017 年 11 月,瑞典哈兰省某会议场所发生一起 83 例胃肠炎暴发疫情。对 2 名场馆来访者和 1 例经家庭传播的症状性二代病例的粪便样本进行 PCR 检测,结果显示基因阳性,该基因存在于 spp. 和肠侵袭性大肠杆菌(EIEC)中。从粪便样本中分离出 EIEC,全基因组测序分析证实 EIEC O96:H19 为病原体。对场馆来访者和员工进行了队列研究,结果提示受污染的叶菜类可能是感染源,但没有微生物学证据可以支持研究结果。在此,我们报告首例在瑞典记录的 EIEC 暴发疫情,并说明了在暴发环境下对 /EIEC 进行差异化实验室诊断所面临的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bce/7068165/1201e7e6b8f1/1900466-f1.jpg

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