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[一例胰腺癌术后24个月出现肺转移及玛丽·约瑟夫修女结节的手术切除病例]

[A Surgically Resected Case of Lung Metastases and Sister Mary Joseph's Nodule 24 Months after Operation for Pancreatic Cancer].

作者信息

Kono Yuka, Oishi Tatsuro, Ueda Yuki, Matsuoka Eiji, Kamimura Ryousuke, Tokiyoshi Takahiro, Okamoto Takako, Kashima Shiro

机构信息

Dept. of Digestive Surgery, Hyogo Prefectural Awaji Medical Center.

出版信息

Gan To Kagaku Ryoho. 2019 Dec;46(13):2354-2356.

Abstract

Metastatic umbilical tumors from internal malignancy, known as Sister Mary Joseph's Nodule(SMJN), are a relatively rare prognostic sign. An 86-year-old woman with pancreatic body carcinoma underwent distal pancreatectomy for D2 lymph node removal in 20XX. No peritoneal dissemination was found at that time. Postoperative chemotherapy was not administered due to her age. Eighteen months postoperatively, tumor marker values increased and chest computed tomography(CT) revealed a single mass in the left lung. We resected the suspected lung metastasis. Positron emission tomography-CT performed 23 months postoperatively for increased tumor marker values after resection showed a 18F-fluorodeoxyglucose accumulation ofapproximately 4 cm in the umbilicus. The diagnosis by biopsy was umbilical metastasis ofthe pancreatic cancer. No recurrence or other metastases were found, so we performed an umbilical tumor resection and abdominoplasty 24 months postoperatively. No peritoneal dissemination was found in her abdomen and the ascites cytology was negative. The tumor was in the subcutaneous tissue; thus, the possibility of infiltration from the primary site or peritoneal dissemination was low. The tumor marker values decreased after the resection. She was followed-up without postoperative anticancer chemotherapy. However, the tumor marker values increased again, so chemotherapy was initiated. We report a case ofresection of pancreatic cancer and operation for lung and umbilical metastases of pancreatic cancer.

摘要

源自体内恶性肿瘤的转移性脐部肿瘤,即所谓的玛丽·约瑟夫修女结节(SMJN),是一种相对罕见的预后体征。一名86岁患有胰体癌的女性于20XX年接受了远端胰腺切除术以清扫D2淋巴结。当时未发现腹膜播散。由于其年龄原因,术后未进行化疗。术后18个月,肿瘤标志物值升高,胸部计算机断层扫描(CT)显示左肺有一个肿块。我们切除了疑似肺转移灶。术后23个月,因切除术后肿瘤标志物值升高而进行的正电子发射断层扫描-CT显示脐部有一个约4 cm的18F-氟脱氧葡萄糖积聚。活检诊断为胰腺癌脐部转移。未发现复发或其他转移,因此我们在术后24个月进行了脐部肿瘤切除和腹壁成形术。在她的腹部未发现腹膜播散,腹水细胞学检查为阴性。肿瘤位于皮下组织;因此,来自原发部位浸润或腹膜播散的可能性较低。切除术后肿瘤标志物值下降。她在未进行术后抗癌化疗的情况下接受随访。然而肿瘤标志物值再次升高,于是开始化疗。我们报告了一例胰腺癌切除以及胰腺癌肺和脐部转移灶手术的病例。

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